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Table 2 Corticotropin-releasing hormone challenge test

From: Clinical characteristics of patients with unexplainable hypothalamic disorder diagnosed by the corticotropin-releasing hormone challenge test: a retrospective study

 

NR

unexplainable-HD

explainable-HD

PD

Basal plasma ACTH (pg/mL)

19.5 (11.9–27.0)

13.9 (9.6–16.9)

16.9 (13.5–30.4)

13.7 (5.5–26.1)

Basal serum cortisol (μg/dL)

8.8 (6.5–10.9)

6.6 (5.0–7.9)

5.6 (3.5–7.3) a

2.2 (0.6–6.7) b

Peak plasma ACTH (pg/mL)

80.3 (68.0–91.2)

51.5 (41.9–84.8) a

71.7 (48.1–98.7)

21.1 (9.8–43.2) b, d, f

Peak serum cortisol (μg/dL)

19.1 (18.6–22.6)

15.3 (13.3–16.4) b

12.8 (7.6–16.3) b

3.0 (0.5–10.2) b, d, e

Δ Plasma ACTH (pg/mL)

62.7 (50.6–80.8)

39.2 (28.8–67.2) a

50.4 (32.9–68.4)

7.0 (2.8–16.4) b, d, f

Δ Serum cortisol (μg/dL)

11.5 (9.4–14.0)

8.3 (6.9–9.7) a

6.0 (3.1–7.8) b, c

0.6 (0.1–3.5) b, d, f

  1. Data are expressed as median (interquartile range). The Kruskal–Wallis test was used to compare the study groups, and the Steel–Dwass method was used for multiple comparisons. aP < 0.05 and bP < 0.01 compared with the NR group, cP < 0.05 and dP < 0.01 compared with the unexplainable-HD group, and eP < 0.05 and fP < 0.01 compared with the explainable-HD group. ACTH adrenocorticotropic hormone, explainable-HD explainable-hypothalamic disorder group, NR normal response group, PD pituitary disorder group, unexplainable-HD unexplainable-hypothalamic disorder group