Table 1 Comparison of clinical characteristics of the study groups

Age, y

58.5 (36.5–69.8)

39.0 (32.5–46.5)

58.0 (47.5–72.8) ^d

59.0 (49.0–67.5) ^c

Women, n (%)

14 (77.8)

14 (77.8)

15 (39.5) ^{a, c}

3 (20.0) ^{b, d}

Body mass index, kg/m²

23.3 (21.5–25.7)

19.6 (18.9–22.6)

24.2 (21.8–26.8) ^c

21.2 (20.6–22.9)

Hydrocortisone replacement, n (%)

10 (55.6)

6 (33.3)

27 (71.1) ^c

11 (73.3) ^c

 Tumoral (post-surgery)

9 (50.0)

0 (0) ^b

20 (52.6) ^d

4 (26.7)

 Tumoral (non-surgery)

4 (22.2)

0 (0)

11 (29.0)

0 (0)

 irAE

0 (0)

0 (0)

2 (5.3)

6 (40.0) ^{b, d}

 Empty sella syndrome

0 (0)

0 (0)

2 (5.3)

1 (6.7)

 Sheehan syndrome

0

0

1 (2.6)

0

 Sarcoidosis

0

0

1 (2.6)

0

 Pituitary stalk transection

0

0

1 (2.6)

0

 Hypophysitis

2 (11.1)

0 (0)

0 (0)

0 (0)

 Unknown

3 (16.7)

18 (100) ^b

0 (0) ^d

4 (26.7) ^d

Other pituitary hormone deficiencies, n (%)

6 (33.3)

0 (0)

26 (68.4) ^d

4 (26.7)

 Growth hormone

4

0

22

3

 Prolactin

1

0

9

2

 Thyrotropin

5

0

16

3

 Gonadotropin

3

0

22

2

 Antidiuretic hormone

2

0

3

0

Comorbidities, n (%)

 Autoimmune disease

1 (5.6)

3 (16.7)

5 (13.2)

1 (6.7)

 Thyroid autoantibody

2/4 (50.0)

3/10 (30.0)

4/11 (36.4)

1/9 (11.1)

 Allergic disease

0 (0)

6 (33.3) ^b

3 (7.9) ^c

1 (6.7)

 Psychiatric disorder

1 (5.6)

5 (27.8)

0 (0) ^d

1 (6.7)

  Depression

0

4

0

0

  ADHD

0

1

0

0

  Schizophrenia

0

1

0

0

  Panic disorder

0

0

0

1

  Anxiety disorder

1

0

0

0