Ovarian volume, not follicle count, is independently associated with androgens in patients with polycystic ovary syndrome

Mansour, Asieh; Hashemi Taheri, Amir Pejman; Moradi, Behnaz; Mohajeri-Tehrani, Mohammad Reza; Qorbani, Mostafa; Ghorbani Pashakolaee, Sahar; Sanginabadi, Milad; Sajjadi-Jazi, Sayed Mahmoud

doi:10.1186/s12902-022-01224-y

Table 2 Association of ovarian volume and morphology with hormonal parameters

From: Ovarian volume, not follicle count, is independently associated with androgens in patients with polycystic ovary syndrome

Variables	Testosterone		FAI		LH/FSH		HOMA-IR
Variables	β (SE)	P value	β (SE)	P value	β (SE)	P value	β (SE)	P value
PCOM (bilateral vs. unilateral)
Model 1 (unadjusted)	0.098 (0.051)	0.060	0.285 (0.099)	0.006	-0.162 (0.090)	0.079	-0.025 (0.052)	0.629
Model 2	0.104 (0.051)	0.044	0.289 (0.100)	0.005	-0.160 (0.091)	0.086	-0.028 (0.052)	0.597
Model 3	0.116 (0.052)	0.028	0.252 (0.101)	0.015	-0.166 (0.094)	0.084	-0.044 (0.053)	0.402
Model 4	0.119 (0.052)	0.028	0.216 (0.096)	0.029	-0.153 (0.095)	0.113	-0.068 (0.048)	0.164
Right OV (cm ³ )
Model 1 (unadjusted)	0.020 (0.005)	< 0.001	0.037 (0.010)	0.001	0.027 (0.009)	0.006	0.001 (0.006)	0.945
Model 2	0.020 (0.005)	< 0.001	0.037 (0.010)	0.001	0.027 (0.009)	0.007	0.001 (0.006)	0.935
Model 3	0.020 (0.005)	< 0.001	0.038 (0.010)	< 0.001	0.027 (0.010)	0.008	0.001 (0.006)	0.899
Model 4	0.021 (0.005)	< 0.001	0.033 (0.010)	0.001	0.030 (0.009)	0.002	-0.003 (0.005)	0.573
Left OV (cm ³ )
Model 1 (unadjusted)	0.021 (0.006)	0.001	0.041 (0.011)	< 0.001	0.015 (0.011)	0.166	0.001 (0.006)	0.952
Model 2	0.020 (0.006)	0.001	0.040 (0.011)	0.001	0.014 (0.011)	0.192	0.001 (0.006)	0.959
Model 3	0.020 (0.006)	0.002	0.044 (0.011)	< 0.001	0.016 (0.011)	0.152	0.001 (0.006)	0.892
Model 4	0.024 (0.006)	0.001	0.037 (0.012)	0.003	0.024 (0.012)	0.047	-0.007 (0.006)	0.243
^a Right + Left OV (cm ³ )
Model 1 (unadjusted)	0.022 (0.005)	< 0.001	0.045 (0.011)	< 0.001	0.025 (0.010)	0.017	0.001 (0.006)	0.947
Model 2	0.022 (0.005)	< 0.001	0.045 (0.011)	< 0.001	0.025 (0.010)	0.018	0.001 (0.006)	0.955
Model 3	0.022 (0.005)	< 0.001	0.047 (0.010)	< 0.001	0.025 (0.010)	0.019	0.001 (0.006)	0.964
Model 4	0.025 (0.006)	< 0.001	0.041 (0.011)	< 0.001	0.032 (0.011)	0.004	-0.006 (0.006)	0.288
^b AFC
Model 1 (unadjusted)	0.001 (0.001)	0.204	0.003 (0.002)	0.048	-0.001 (0.002)	0.669	0.002 (0.001)	0.046
Model 2	0.001 (0.001)	0.186	0.003 (0.002)	0.051	-0.001 (0.002)	0.685	0.002 (0.001)	0.049
Model 3	0.001 (0.001)	0.119	0.003 (0.002)	0.110	-0.001 (0.002)	0.658	0.001 (0.001)	0.103
Model 4	0.001 (0.001)	0.122	0.001 (0.002)	0.383	0.001 (0.002)	0.858	0.001 (0.001)	0.346
^a 2-5 mm FNPO
Model 1 (unadjusted)	0.002 (0.002)	0.389	0.006 (0.004)	0.151	0.004 (0.004)	0.303	0.004 (0.002)	0.029
Model 2	0.001 (0.002)	0.529	0.006 (0.004)	0.175	0.003 (0.004)	0.417	0.004 (0.002)	0.020
Model 3	0.002 (0.002)	0.393	0.006 (0.004)	0.183	0.003 (0.004)	0.453	0.004 (0.002)	0.030
Model 4	0.002 (0.002)	0.417	0.003 (0.004)	0.487	0.004 (0.004)	0.317	0.003 (0.002)	0.088
^a 6-9 mm FNPO
Model 1 (unadjusted)	0.003 (0.007)	0.678	-0.008 (0.014)	0.564	0.001 (0.013)	0.989	0.002 (0.007)	0.751
Model 2	0.006 (0.007)	0.380	-0.007 (0.014)	0.613	0.004 (0.013)	0.788	0.001 (0.007)	0.851
Model 3	0.007 (0.007)	0.379	-0.007 (0.014)	0.596	0.004 (0.013)	0.788	0.001 (0.007)	0.862
Model 4	0.007 (0.007)	0.378	-0.006 (0.012)	0.603	0.003 (0.013)	0.803	0.002 (0.006)	0.807
^a 2-9 mm FNPO
Model 1 (unadjusted)	0.001 (0.001)	0.331	0.003 (0.003)	0.299	0.003 (0.003)	0.276	0.003 (0.001)	0.021
Model 2	0.002 (0.001)	0.283	0.003 (0.003)	0.309	0.003 (0.003)	0.260	0.003 (0.001)	0.024
Model 3	0.002 (0.001)	0.226	0.002 (0.003)	0.440	0.003 (0.003)	0.267	0.003 (0.001)	0.041
Model 4	0.002 (0.002)	0.233	0.001 (0.003)	0.899	0.004 (0.003)	0.142	0.002 (0.001)	0.184
^a Ovarian area (cm ² )
Model 1 (unadjusted)	0.017 (0.014)	0.240	0.031 (0.027)	0.248	0.029 (0.024)	0.245	0.014 (0.013)	0.276
Model 2	0.014 (0.014)	0.321	0.030 (0.027)	0.269	0.028 (0.025)	0.270	0.014 (0.013)	0.289
Model 3	0.014 (0.014)	0.345	0.032 (0.027)	0.236	0.028 (0.025)	0.268	0.015 (0.013)	0.250
Model 4	0.013 (0.014)	0.364	0.027(0.025)	0.227	0.029 (0.025)	0.259	0.013 (0.012)	0.305
^a Stromal area (cm2)
Model 1 (unadjusted)	0.009 (0.013)	0.502	0.031 (0.025)	0.214	0.008 (0.023)	0.726	0.013 (0.012)	0.275
Model 2	0.007 (0.013)	0.607	0.032 (0.025)	0.204	0.007 (0.024)	0.777	0.014 (0.012)	0.251
Model 3	0.007 (0.013)	0.578	0.030 (0.025)	0.229	0.007 (0.024)	0.784	0.013 (0.012)	0.280
Model 4	0.007 (0.013)	0.572	0.035 (0.022)	0.121	0.005 (0.024)	0.835	0.016 (0.011)	0.165
^a S/A
Model 1 (unadjusted)	0.005 (0.190)	0.978	-0.102 (0.354)	0.775	0.169 (0.322)	0.602	0.085 (0.174)	0.629
Model 2	-0.021 (0.188)	0.912	-0.114 (0.359)	0.752	0.158 (0.326)	0.631	0.082 (0.176)	0.643
Model 3	-0.011 (0.188)	0.955	-0.140 (0.356)	0.697	0.153 (0.330)	0.646	0.069 (0.174)	0.694
Model 4	0.005 (0.195)	0.978	0.083 (0.337)	0.806	0.131 (0.343)	0.703	0.184 (0.163)	0.264

AFC antral follicle count, FAI free androgen index, FNPO follicle number per ovary, FSH follicle-stimulating hormone, HOMA-IR homeostasis model assessment of insulin resistance, LH luteinizing hormone, OV ovarian volume, PCOM polycystic ovarian morphology, S/A stromal to ovarian area ratio
Model 2 includes variables from model 1 plus age; Model 3 includes variables from model 1 plus age and mensuration status; Model 4 includes variables from model 1 plus age, mensuration status and BMI
^aThe mean value of the left and right ovary was used for analysis
^bSum of follicles in both ovaries

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