Dietary glycemic index and glycemic load mediate the effect of CARTPT rs2239670 gene polymorphism on metabolic syndrome and metabolic risk factors among adults with obesity

Table 3 Results from Structural Equation Modeling of relations between the CARTPT rs2239670 polymorphism, diet, socio-demographic and psychological variables and serum glycemic levels and lipid profile among individuals with obesity

Model Path	Standardized estimate^a	SE	P
Model 1 Direct effects
Appetite → GL	1.356	0.463	0.003
Gender → TG	−24.740	8.516	0.004
Triglyceride → LDL-C	−0.200	0.001	0.000
HDL → LDL-C	−0.999	0.004	0.000
Cholesterol → LDL-C	1.001	0.001	0.000
Triglyceride → HDL	−0.0435	0.011	0.000
Gender → HDL	3.885	1.228	0.002
Age → Cholesterol	0.938	0.333	0.005
Indirect effects via GI and GL
Age →LDL-C	0.917	0.332	0.006
Gender → HDL	1.047	0.484	0.031
Model 2
Direct effects
Appetite → GL	1.358	0.464	0.003
Stress → Insulin	0.007	0.002	0.001
Age → Insulin	0.006	0.003	0.023
Model 3
Direct effects
CARTPT→MetS	0.037	0.022	0.043
Indirect effects via GI
CARTPT→ MetS	0.039	0.017	0.009

Abbreviations: GI Glycemic index, GL Glycemic load, LDL Low density lipoprotein, HDL High-density lipoprotein, MetS Metabolic syndrome, CARTPT Cocaine- and amphetamine-regulated transcript, SE Standard error of the estimate; All standardized path coefficients shown were significant (P < 0.05)
^aStandardized path coefficients

ISSN: 1472-6823