Table 4 Mixed effect regression analysis of body mass index (BMI). Associations are presented as β as well as well as standardized β coefficients with 95% confidence intervals CI’s, studying group*time interaction, adjusting for group status, follow-up time age, sex, education, baseline proneurotensin, baseline fasting glucose and baseline insulin sensitivity index

Follow-up time, months

-1.01 ( -0.09, 0.06)

-0.39

0.696

-0.01 ( -0.09, 0.06)

-0.39

0.699

-0.02 (-0.10,0.07)

-0.36

0.715

Group status (Intervention group)

1.47 (-0.15, 3.10)

1.77

0.076

1.61 (-0.07, 3.28)

1.85

0.064

2.08 (0.34,3.82)

2.264

0.024

Group status*time^a

-0.13 (-0.02, -0.03)^*

-2.46^*

0.014 ^*

-0.13 (-0.02, -0.03)^*

-2.45^*

0.014 ^*

-0.12^* (-0.24, -0.01)

-2.19^*

0.028

Age, years

-0.01 (-0.09, 0.08)

-0.12

0.902

-0.03 (-0.12, 0.06)

0.68

0.497

Male sex

0.47 (-0.14, 2.08)

0.56

0.574

0.15 (-1.55, 1.84)

0.16

0.871

Education (high vs. low)

0.62 (-2.56, 1.32)

-0.62

0.547

-055 (-2.59, 1.49)

-0.51

0.609

Baseline proNT pmol/L

0.02 (0.01, 0.04)^*

0.57^*

0.041

Baseline fasting blood glucose mmol/l

0.41 (-0.97, 0.07)

2.05

0.571

Baseline ISI

-0.01 (-0.02, 0.01)

-0.47

0.637