Circulating endocannabinoid levels in pregnant women with gestational diabetes mellitus: a case–control study

BMC Endocrine Disorders

Table 5 Odds ratios (95% CI) for gestational diabetes according to endocannabinoids (AEA and 2-AG) and anthropometric indices (weight, weight gain, and BMI)

Variable	Or (CI)	B^a	*P- value
AEA (ng/ml)
Model 1	1.22 (1.06–1.41)	0.20	0.004
Model 2	1.54 (1.19–1.97)	0.43	0.001
Model 3	1.46 (1.11–1.91)	0.37	0.006
Model 4	1.38 (0.99–1.92)	0.32	0.05
2-AG (ng/ml)
Model 1	1.22 (1.06–1.41)	0.20	0.004
Model 2	1.33 (1.10–1.61)	0.28	0.003
Model 3	1.23 (1.007–1.50)	0.20	0.04
Model 4	1.25 (0.94–1.65)	0.22	0.11
Weight (kg)
Model 1	1.14 (1.04–1.26)	0.13	0.006
Model 2	1.11 (0.99–1.23)	0.10	0.05
Model 3	1.05 (0.92–1.20)	0.05	0.40
Model 4	1.003 (0.85–1.17)	0.003	0.97
Weight gain (kg)
Model 1	1.93 (1.35- 2.74)	0.65	< 0.001
Model 2	2.07 (1.28–3.33)	0.72	0.003
Model 3	1.87 (1.12- 3.12)	0.62	0.01
Model 4	3.24 (1.55–6.80)	1.17	0.002
BMI (kg/m²)
Model 1	2.06 (1.38- 3.06)	0.72	< 0.001
Model 2	1.59 (1.04–2.43)	0.46	0.02
Model 3	1.54 (0.77- 3.05)	0.43	0.21
Model 4	2.18 (0.88- 5.42)	0.78	0.09

Abbreviation: AEA Anandamide, 2-AG 2-Arachidonoylglycerol, BMI Body mass index
^a B coefficient; regression slope
^* P < 0.05 statistically significant by Multivariable logistic regression. Model 1: unadjusted, model 2: adjusted for energy, carbohydrate, protein, and fat, model 3: adjusted for energy, carbohydrate, protein, and fat, weight gain, and BMI, model 4: adjusted for energy, carbohydrate, protein, and fat, weight gain, BMI, age, education, job, level of physical activity, sex of infant, family history of type 2 diabetes and gestational diabetes, number of pregnancies and weeks of pregnancy

ISSN: 1472-6823