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Table 3 Associations between HbA1c and liver steatosis based on CAP value

From: Association of glycated hemoglobin with non-alcoholic fatty liver disease patients and the severity of liver steatosis and fibrosis measured by transient elastography in adults without diabetes

 

Model 1

β (95% CI), P value

Model 2

β (95% CI), P value

Model 3

β (95% CI), P value

HbA1c

37.448 (31.771, 43.125) < 0.001

34.472 (28.301, 40.643) < 0.001

13.437 (8.282, 18.592) < 0.001

Q1(4.1–5.1%)

Reference

Reference

Reference

Q2(5.2–5.4%)

4.832 (-0.790, 10.454) 0.092

2.777 (-2.750, 8.304) 0.32483

-1.596 (-6.062, 2.870) 0.484

Q3(5.5–5.6%)

14.606 (8.349, 20.864) < 0.001

12.324 (5.934, 18.714) < 0.001

2.979 (-2.221, 8.179) 0.262

Q4(5.7–6.4%)

35.043 (29.137, 40.950) < 0.001

31.389 (25.068, 37.709) < 0.001

12.209 (6.952, 17.467) < 0.001

P for trend

 < 0.001

 < 0.001

< 0.001

Subgroup analysis

  Normoglycemic levels (n = 1635)

15.517 (5.248, 25.786) 0.003

5.843 (-4.707, 16.392) 0.278

-2.230 (-10.853, 6.393) 0.612

  Prediabetes (n = 1363)

18.423 (9.287, 27.559) < 0.001

30.390 (20.862, 39.918) < 0.001

18.905 (10.737, 27.074) < 0.001

  Pinteraction

  

< 0.001

  1. Model 1: no covariates were adjusted
  2. Model 2: sex, age, and race were adjusted
  3. Model 3: sex, age, race, hypertension, smoking status, BMI, WC, activity level, hemoglobin, dyslipidemia, and HOMA-IR were adjusted
  4. Abbreviations: NAFLD Non-alcoholic fatty liver disease, HbA1c Glycosylated hemoglobin, BMI Body mass index, WC Waist circumference, HOMA-IR Homeostasis model assessment of insulin resistance
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BMC Endocrine Disorders

ISSN: 1472-6823

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