Are there any interactions between modified Nordic-style diet score and MC4R polymorphism on cardiovascular risk factors among overweight and obese women? A cross-sectional study

Hosseininasab, Dorsa; Mirzababaei, Atieh; Abaj, Faezeh; Firoozi, Roya; Clark, Cain C. T.; Mirzaei, Khadijeh

doi:10.1186/s12902-022-01132-1

Table 4 The interaction of MC4R genotypes and MND on CVD risk factors*

From: Are there any interactions between modified Nordic-style diet score and MC4R polymorphism on cardiovascular risk factors among overweight and obese women? A cross-sectional study

Variables	models	alleles	T2			T3
			β	95% CI	P-value	β	95% CI	P-value
BMI (kg/m²)	Crude	TT		References	0.70		References	0.93
	Crude	TC + CC	0.58	-2.46 to 3.63	0.70	0.12	-2.85 to 3.10	0.93
	Adjusted	TT		References	0.71		References	0.94
	Adjusted	TC + CC	0.50	-2.18 to 3.20	0.71	-0.08	-2.71 to 2.54	0.94
WC (cm)	Crude	TT		References	0.58		References	0.70
	Crude	TC + CC	1.95	-5.13 to 9.04	0.58	1.34	-5.58 to 8.26	0.70
	Adjusted	TT		References	0.57		References	0.77
	Adjusted	TC + CC	1.94	-4.85 to 8.74	0.57	0.97	-5.66 to 7.62	0.77
WHR	Crude	TT		References	0.36		References	0.99
	Crude	TC + CC	1.75	-2.05 to 5.56	0.36	0.01	-3.70 to 3.73	0.99
	Adjusted	TT		References	0.39		References	0.85
	Adjusted	TC + CC	1.87	-2.41 to 6.16	0.39	-0.40	-4.58 to 3.78	0.85
BFM (kg)	Crude	TT		References	0.42		References	0.54
	Crude	TC + CC	2.50	-3.60 to 8.60	0.42	1.86	-4.10 to 7.82	0.54
	Adjusted	TT		References	0.49		References	0.79
	Adjusted	TC + CC	1.99	-3.66 to 7.66	0.49	0.73	-4.79 to 6.26	0.79
FFM (kg)	Crude	TT		References	0.98		References	0.40
	Crude	TC + CC	0.03	-3.84 to 3.90	0.98	-1.62	-5.40 to 2.16	0.40
	Adjusted	TT		References			References	0.32
	Adjusted	TC + CC	-0.21	-4.19 to 3.75	0.91	-1.95	-5.84 to 1.92	0.32
VFL	Crude	TT		References	0.07		References	0.03
	Crude	TC + CC	-9.23	-19.25 to 0.79	0.07	-10.84	-20.64 to -1.04	0.03
	Adjusted	TT		References	0.07		References	0.03
	Adjusted	TC + CC	-10.25	-21.53 to 1.02	0.07	-12.22	-23.24 to -1.20	0.03
HOMA-IR	Crude	TT		References	0.54		References	0.87
	Crude	TC + CC	0.29	-0.65 to 1.23	0.54	-0.07	-1.06 to 0.90	0.87
	Adjusted	TT		References	0.70		References	0.82
	Adjusted	TC + CC	0.19	-0.81 to 1.21	0.70	0.11	-0.93 to 1.17	0.82
Total Cholesterol (mg/dl)	Crude	TT		References	0.01		References	0.06
	Crude	TC + CC	-34.64	-61.30 to -7.97	0.01	-24.24	-49.87 to 1.38	0.06
	Adjusted	TT		References	< 0.001		References	0.20
	Adjusted	TC + CC	-38.79	-65.00 to -12.58	< 0.001	-16.29	-41.35 to 8.77	0.20
TG (g/dl)	Crude	TT		References	0.62		References	0.79
	Crude	TC + CC	-13.17	-65.80 to 39.44	0.62	-6.70	-57.28 to 43.87	0.79
	Adjusted	TT		References	0.61		References	0.72
	Adjusted	TC + CC	-14.31	-70.39 to 41.76	0.61	9.51	-44.11 to 63.15	0.72
HDL (mg/dl)	Crude	TT		References	0.75		References	0.46
	Crude	TC + CC	-1.30	-9.53 to 6.92	0.75	-2.94	-10.85 to 4.96	0.46
	Adjusted	TT		References	0.77		References	0.72
	Adjusted	TC + CC	1.23	-7.25 to 9.71	0.77	-1.44	-9.56 to 6.67	0.72
LDL (mg/dl)	Crude	TT		References	0.01		References	0.17
	Crude	TC + CC	-21.69	-39.71 to -3.67	0.01	-11.90	-29.22 to 5.41	0.17
	Adjusted	TT		References	0.03		References	0.53
	Adjusted	TC + CC	-18.77	-36.59 to -0.95	0.03	-5.41	-22.45 to 11.62	0.53
LDL/HDL	Crude	TT		References	0.06		References	0.52
	Crude	TC + CC	-0.08	-0.18 to 0.00	0.06	-0.02	-0.11 to 0.06	0.52
	Adjusted	TT		References	0.04		References	0.70
	Adjusted	TC + CC	-0.96	-0.19 to -0.00	0.04	-0.01	-0.10 to 0.07	0.70
CHOL/HDL	Crude	TT		References	0.06		References	0.20
	Crude	TC + CC	-1.08	-1.81 to 0.39	0.06	-0.70	-1.81 to 0.39	0.20
	Adjusted	TT		References	0.01		References	0.19
	Adjusted	TC + CC	-1.50	-2.23 to 0.05	0.01	-0.76	-1.91 to 0.39	0.19
hs-CRP (mg/ L)	Crude	TT		References	0.07		References	0.34
	Crude	TC + CC	-3.24	-6.76 to 0.26	0.07	-1.63	-4.99 to 1.72	0.34
	Adjusted	TT		References	0.12		References	0.51
	Adjusted	TC + CC	-2.90	-6.62 to 0.80	0.12	-1.17	-4.72 to 2.37	0.51

TT genotype has 0 risk allele. TC genotype has one and CC genotype have two risk alleles
TT genotype and Low adherence to MND are considered as references
Generalized linear model; crude model and adjusted model to BMI, physical activity, kcal, age, family history of obesity, and occupation, as covariates
BMI Body mass index, WC waist circumference, WHR waist height ratio, BFM body fat mas, FFM fat free mass, VFL visceral fat level, TG Triglyceride, LDL Low density lipoprotein, HDL, High density lipoprotein, CHOL cholesterol, hs-CRP High sensitivity C-reactive protein
^*For interactions, P < 0.1 was considered significant

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