Table 3 Levothyroxine dosages at different time points for the four patient groups (μg/kg. d)

At diagnosis

9.12 ± 2.43

7.9 ± 2.19

6.28 ± 2.40

4.47 ± 2.03

28.17

< 0.0001

2 weeks

8.76 ± 2.68

7.6 ± 2.18

5.19 ± 2.03

4.24 ± 1.93

21.77

< 0.0001

1 month

7.35(5.81,9.15)

6.96(6.1,8.33)

4.72(4.72,4.72)

3.3(2.47,4.91)

51.4976

< 0.0001

3 months

5.7(3.99,7.43)

5.15(3.85,5.77)

3.11(3.11,3.11)

2.86(2.08,3.39)

50.793

< 0.0001

6 months

4.14(3.11,4.9)

3.43(2.94,4.17)

2.67(2.67,2.67)

2.17(1.43,3.01)

40.3017

<.0001

12 months

3.2(2.53,3.89)

2.5(2.31,2.87)

2.21(2.21,2.21)

1.69(1.1,2.5)

38.6064

<.0001

18 months

2.9(2.2,3.57)

2.23(1.64,2.46)

2.07(2.07,2.07)

1.6(1.19,2.12)

28.1057

<.0001

24-month

2.95 ± 0.92

2.27 ± 1

1.97 ± 0.8

1.58 ± 0.51

10.43

<.0001

36-month

2.5(2.24,3.6)

1.68(1.12,2.99)

1.69(1.69,1.69)

1.22(1.08,1.8)

15.4036

0.0015