Table 1 Characteristics of the included studies
From: Diagnostic value of serum cystatin C for diabetic nephropathy: a meta-analysis
First author | Year | Region | Diabetic nephropathy type | Cys-C detection method | case (control) | Cut-off value | TP | FP | FN | TN | Sensitivity | Specificity | reference for GFR/ACR/AER |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mojiminiyi [22] | 2000 | Kuwait | T2DM | PENIA | 50(27) | NR | 20 | 3 | 30 | 24 | 0.4 | 0.89 | ACR |
Oddoze C [23] | 2001 | France | T1DM, T2DM | PENIA | 10(39) | 0.96Â mg/L | 9 | 4 | 1 | 35 | 0.9 | 0.9 | GFR |
Christensson AG [24] | 2004 | Sweden | T1DM, T2DM | PETIA | 15(108) | NR | 14 | 3 | 1 | 105 | 0.9333 | 0.9722 | GFR |
Bicik Z [25] | 2005 | Turkish | T2DM | PETIA | 32(40) | 1.4Â mg/L | 29 | 4 | 3 | 36 | 0.9 | 0.9 | GFR |
Beauvieux MC [26] | 2007 | France | T1DM, T2DM | PENIA | 76(48) | 0.96Â mg/L | 70 | 6 | 6 | 42 | 0.921 | 0.875 | GFR |
Macisaac [27] | 2007 | Australia | T1DM, T2DM | PENIA | 54(197) | 1.1Â mg/L | 53 | 20 | 1 | 177 | 0.981 | 0.898 | GFR |
Pucci [28] | 2007 | Italy | T1DM, T2DM | PENIA | 218(70) | 1.23Â mg/L | 168 | 2 | 50 | 68 | 0.77 | 0.97 | GFR |
Kimura [29] | 2008 | Japan | T2DM | Latex agglutination test | 118(171) | 0.85Â mg/L | 111 | 15 | 7 | 156 | 0.94 | 0.91 | GFR |
Rigalleau V [30] | 2008 | France | T1DM, T2DM | PETIA | 76(48) | 1.10Â mg/L | 70 | 9 | 6 | 39 | 0.921 | 0.8125 | GFR |
Iliadis F [31] | 2011 | Greece | T2DM | PETIA | 145(303) | NR | 118 | 61 | 27 | 242 | 0.812 | 0.798 | GFR |
Jeon [32] | 2011 | Korea | T2DM | Latex agglutination test | 29(181) | 1.06Â mg/L | 23 | 23 | 6 | 158 | 0.81 | 0.871 | GFR |
Bevc S [33] | 2012 | Slovenia | T2DM | PENIA | 86(27) | NR | 73 | 0 | 13 | 27 | 0.849 | 1 | GFR |
Chae HW [34] | 2012 | Korea | T1DM, T2DM | PENIA | 20(93) | NR | 17 | 31 | 3 | 62 | 0.873 | 0.662 | GFR |
Wang H [35] | 2012 | China | T2DM | NR | 60(55) | 1.55Â mg/L | 52 | 3 | 8 | 52 | 0.867 | 0.95 | AER |
Assal [36] | 2013 | Egypt | T2DM | PETIA | 25(20) | 2.45Â mg/L | 18 | 3 | 2 | 17 | 0.708 | 0.833 | NR |
Tan TT [37] | 2015 | China | T2DM | NR | 47(111) | 1.48Â mg/L | 38 | 11 | 9 | 100 | 0.809 | 0.904 | ACR |
Cao YY [38] | 2015 | China | T2DM | Turbidimetric inhibition immunoassay | 60(43) | 0.86Â mg/L | 56 | 3 | 4 | 40 | 0.9333 | 0.9277 | ACR |
Yang N [39] | 2017 | China | T1DM, T2DM | NR | 103(85) | 1.06Â mg/L | 88 | 29 | 15 | 56 | 0.8564 | 0.6531 | ACR |
Zhang HF [40] | 2018 | China | T2DM | Immune colloidal gold technique | 265(165) | 1.1Â mg/L | 176 | 9 | 89 | 156 | 0.665 | 0.945 | ACR |
Zhang RL [41] | 2018 | China | T2DM | NR | 100(100) | NR | 79 | 26 | 21 | 74 | 0.789 | 0.744 | NR |
Mohammed [42] | 2019 | Egypt | T2DM | PENIA | 20(30) | 1.6Â mg/L | 19 | 2 | 1 | 28 | 0.96 | 0.94 | ACR |
Xu WH [43] | 2019 | China | T2DM | NR | 25(28) | 1.12Â mg/L | 20 | 3 | 5 | 25 | 0.8 | 0.8929 | AER |
Wang HF [44] | 2019 | China | T2DM | PENIA | 28(30) | 1.75Â mg/L | 23 | 3 | 5 | 27 | 0.829 | 0.895 | ACR |
Salem [45] | 2020 | Egypt | T1DM | ELISA | 31(29) | 0.605Â mg/L | 27 | 5 | 4 | 24 | 0.883 | 0.833 | ACR |
Wang SY [46] | 2020 | China | T1DM, T2DM | Immunoturbidimetry assay | 67(65) | 2.35Â mg/L | 52 | 5 | 15 | 60 | 0.7835 | 0.9217 | NR |
Guang SF [47] | 2020 | China | T2DM | PENIA | 68(52) | 1.57Â mg/L | 63 | 17 | 5 | 35 | 0.926 | 0.673 | AER |