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Table 3 Comparison of thyroid hormone levels in T2DM patients with or without NAFLD based on the NFS level

From: Correlation between the thyroid hormone levels and nonalcoholic fatty liver disease in type 2 diabetic patients with normal thyroid function

 

T2DM with progressive liver fibrosis

p value

T2DM without progressive liver fibrosis

p value

NFS > 0.676(n = 93)

NFS < 0.676(493)

without NAFLD (n = 45)

with NAFLD (n = 48)

without NAFLD (n = 195)

with NAFLD (n = 298)

Sex (male/female)

13/32

21/27

0.137

88/107

141/157

0.634

Age (years)

72.27 ± 8.14

69.92 ± 8.92

0.189

60(53–66)

56(51–64)

0.025

FT3(pmol/L)

3.81 ± 0.56

3.95 ± 0.50

0.199

3.98 ± 0.50

4.06 ± 0.47

0.081

FT4(pmol/L)

13.04 ± 1.57

12.55 ± 1.40

0.113

13.47 ± 1.51

13.12 ± 2.49

0.013

TT3(nmol/L)

1.29 ± 0.20

1.36 ± 0.20

0.067

1.40 ± 0.22

1.42 ± 0.23

0.215

TT4(nmol/L)

83.67 ± 11.55

83.08 ± 13.58

0.822

85.05(75.20–97.68)

84.61(73.27–95.96)

0.342

TSH (uIU/L)

2.3177 ± 0.9937

2.5104 ± 1.1098

0.381

2.0187(1.4134–2.8459)

2.0308(1.3439–2.7457)

0.537

FT3/FT4

0.295 ± 0.052

0.317 ± 0.045

0.032

0.298 ± 0.042

0.312 ± 0.045

0.000

  1. The measured data of the normal distribution was represented by mean ± SD. Measurement data for non-normal distributions were expressed as medians (interquartile intervals) *p < 0.05,**p < 0.01, ***p < 0.005,with NAFLD vs without NAFLD
  2. NAFLD Nonalcoholic fatty liver disease, T2DM Type 2 diabetes mellitus, BMI Body mass index, NFS NAFLD fibrosis score, FT3 Free triiodothyronine, FT4 Free thyroxine, TT3 Total triiodomethylamine, TT4 Total thyroxine, TSH Thyroid stimulating hormone