Table 2 Transition of clinical parameters in patients with ICI-induced hypopituitarism
Baseline | Last visit | Onset | p-value | |
|---|---|---|---|---|
WBC count (/µL) | 6805 ± 1359 | 6698 ± 1253 | 6905 ± 1076 | 0.919 |
Neutrophil count (/µL) | 4903 ± 1121 | 4295 ± 1291 | 4022 ± 874 | 0.153 |
Lymphocyte count (/µL) | 1294 ± 474 | 1560 ± 371 | 1738 ± 531 | 0.076 |
Eosinophil count (/µL) | 99 [74–177] | 389 ± 261 | 588 ± 304 | < 0.001 |
Sodium level (mmol/L) | 139 ± 2.1 | 139 ± 3.1 | 137.5 [135–138] | 0.056 |
Potassium level (mmol/L) | 4.58 ± 0.33 | 4.42 ± 0.42 | 4.29 ± 0.28 | 0.148 |
Glucose level (mg/dL) | 118 ± 27 | 124 ± 35 | 95 [82–106] | 0.059 |
Blood urea nitrogen level (mg/dL) | 17.2 ± 3.5 | 20.5 ± 3.5 | 18.9 ± 6.9 | 0.265 |
Creatinine level (mg/dL) | 0.93 [0.86–1.00] | 1.15 ± 0.26 | 1.15 [1.07–1.32] | 0.184 |
Hyponatremia, n | 0 | 2 | 3 | 0.247 |
Hyperkalemia | 0 | 0 | 0 | 1.000 |
Hypoglycemia, n | 0 | 0 | 2 | 0.135 |
Hypereosinophilia, n | 0 | 4 | 5 | 0.015 |