Table 2 The effect of TMB level on signaling pathways
Pathway | Variation trend | NOM p-value | Functions in cancer |
|---|---|---|---|
Homologous recombination | Enriched in high TMB | 0.008 | Main steps in DNA double-strand break repair. |
P53 | Enriched in high TMB | 0.000 | Tumor suppressor protein. |
Butanoate metabolism | Enriched in low TMB | 0.017 | 1. An anticancer ingredient. 2. Butanoate metabolism is disrupted in breast cancer. |
Tyrosine metabolism | Enriched in low TMB level | 0.008 | Tyrosine kinase family encompasses the greatest number of oncoproteins. |
Histidine metabolism | Enriched in low TMB level | 0.028 | Histidine metabolism can increase the effectiveness of methotrexate treatment. |
Bile acid metabolism | Enriched in low TMB level | 0.035 | Bile acids have been proposed to promote colon carcinogenesis. |
Cytochrome P450 | Enriched in low TMB level | 0.002 | Cytochrome P450 enzymes play key roles in bile acid synthesis. |