Table 4 Association between TPO-Ab and thyroid immune related adverse effect and subgroup analysis
|  | Positive TPO-Ab (N = 7) | Negative TPO-Ab (N = 46) | P-value |
|---|---|---|---|
Presence of thyroid irAE | Â | Â | 0.099 |
 Thyroid irAE | 5 (71.4%) | 16 (34.8%) |  |
 No thyroid irAE | 2 (28.6%) | 30 (65.2%) |  |
Type of thyroid irAE | |||
 Newly developed overt hypothyroidism | 2 (28.6%) | 12 (26.1%) | 1.000 |
 Worsened hypothyroidism | 3 (42.9%) | 1 (2.2%) | 0.006 |
 Subclinical hyperthyroidism | 0 (0%) | 3 (6.5%) | 1.000 |