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Fig. 8 | BMC Endocrine Disorders

Fig. 8

From: Suppression of MIR31HG affects the functional properties of thyroid cancer cells depending on the miR-761/MAPK1 axis

Fig. 8

MIR31HG suppression hinders the growth of xenograft tumors. A Growth curves of the subcutaneous xenografts produced by sh-MIR31HG-infected or sh-NC-transduced TPC-1 cells (n = 6 per group). B Representative images and average weight of the subcutaneous xenografts formed by TPC-1 cells transduced with sh-MIR31HG or sh-NC (day 22, n = 6 per group). C Effects of the transduction of sh-MIR31HG and sh-NC on MIR31HG and miR-761 expression in the subcutaneous xenografts (day 22, n = 6 per group) by qRT-PCR, normalized to β-actin or U6 expression. D Effects of the transduction of sh-MIR31HG and sh-NC on MAPK1 protein expression in the subcutaneous xenografts (day 22, n = 6 per group) by immunoblotting, with GAPDH as a loading control for relative protein quantification. E Representative immunohistochemical analysis of tumor sections from subcutaneous xenografts (day 22, n = 6 per group) in stained for Ki67, MAPK1, and MMP9. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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BMC Endocrine Disorders

ISSN: 1472-6823

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