Changes in glycemic variability, gastric emptying and vascular endothelial function after switching from twice-daily to once-weekly exenatide in patients with type 2 diabetes: a subpopulation analysis of the twin-exenatide study

Table 3 Associations between ¹³ C-acetate breath test (T_max), vascular endothelial function (reactive hyperemia index) and inflammation/oxidative stress markers and CGM indices in pooled data of week 0 and week 24

	Δ2h post-breakfast	Δ2h post-dinner	SD glucose	CV glucose	MAGE	Time in range	Time above range	Time below range
T_max (min)	-0.470**	-0.450**	-0.255	-0.095	-0.275*	0.351*	-0.310*	0.038
Reactive hyperemia index	-0.028	0.243	0.123	0.024	0.056	-0.212	0.164	-0.102
Adiponectin (µg/ml)	0.250	0.048	0.067	0.238	0.148	0.060	-0.086	0.131
High-sensitivity CRP (mg/dl)	0.007	0.110	0.222	0.056	0.126	-0.312*	0.223	0.088
Urinary 8-OHdG (ng/mg creatinine)	0.165	0.012	0.264*	0.274*	0.296*	-0.223	0.175	0.197
Urinary 8-isoPGF2α (pg/mg creatinine)	0.233	0.159	0.247	0.180	0.213	-0.181	0.190	-0.029

CGM continuous glucose monitoring, SD standard deviation, CV coefficient of variation, MAGE mean amplitude of glycemic excursions, 8-OHdG 8-hydroxy-2’-deoxyguanosine, 8-isoPGF2α 8-isoprostaglandin F2α, Δ2h post-breakfast; glucose level at 2 h after breakfast – pre-breakfast, Δ2h post-dinner; glucose level at 2 h after dinner – pre-dinner. *P < 0.05 and **P < 0.01

ISSN: 1472-6823