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Table 1 A brief history of diabetes mellitus research and development [6,7,8]

From: The many faces of diabetes. Is there a need for re-classification? A narrative review

Time Development
  Variations of diets
550 Common Era (CE) Bleeding, emetics and narcotics
1921 Discovery of insulin
1923 Commercial animal insulin available
1936 Introduction of long-acting insulin
1941 Urine-testing tablets for sugar available
1949 Syringe drivers for insulin
1961 Glucagon available for hypoglycemia
1971 The first blood glucose meter developed
1972 Metformin approved for use in Canada
1983 Recombinant insulin developed
1995 First Alpha-glucosidase inhibitor (AGI) Acarbose
1996 First Thiazolidinedionederivate (TZD) Troglitazone
1997 First Meglitinide Repaglinide
2005 First Amylin agonist pramlintide
First Glucagon-Like Peptide 1(GLP-1) receptor agonist (exenatide)
2006 First Dipeptidyl peptidase-4 (DPP-4) inhibitor (sitagliptin)
2008 Colesevelam approved for diabetes
2009 Bromocriptine approved for diabetes
2013 First Sodium Glucose Transporter-2 (SGLT-2) inhibitor (canagliflozin)