| NTF | Subclinical hypothyroidism | Severe NTIS | Mild to moderate NTIS | P values |
---|---|---|---|---|---|
No. of participants | 184 | 17 | 11 | 23 | Â |
White blood cell count, ×109/L | 6.26 (0.20) | 6.52 (0.66) | 9.33 (0.81) | 7.59 (0.59) | 0.001 |
Neutrophil count, ×109/L | 4.23 (0.19) | 4.41 (0.60) | 8.14 (0.75) | 6.22 (0.54) | < 0.001 |
Lymphocyte count, ×109/L | 1.50 (0.07) | 1.48 (0.21) | 0.71 (0.27) | 0.88 (0.19) | 0.002 |
CRP, mg/L | 17.6 (2.59) | 7.65 (8.25) | 82.0 (10.3) | 67.4 (7.37) | < 0.001 |
Prothrombin time, s | 13.0 (0.30) | 13.0 (0.99) | 17.8 (1.16) | 13.9 (0.90) | 0.001 |
ESR, mm/h | 43.9 (2.73) | 31.0 (9.23) | 55.3 (13.8) | 81.5 (8.50) | < 0.001 |
APTT, s | 39.7 (2.26) | 35.1 (7.61) | 39.8 (8.91) | 44.3 (6.88) | 0.843 |
D-Dimer > 0.5 mg/L, % | 57 (38.0) | 8 (72.7) | 5 (62.5) | 14 (77.8) | 0.001 |
Fibrinogen, g | 3.79 (0.08) | 3.29 (0.27) | 4.72 (0.32) | 3.88 (0.25) | 0.009 |
Thrombin time, s | 16.4 (0.71) | 15.4 (2.40) | 16.5 (2.81) | 16.3 (2.17) | 0.982 |
ALT, U/L | 43.1 (2.46) | 33.4 (8.05) | 46.7 (10.0) | 45.8 (7.18) | 0.631 |
AST, U/L | 32.5 (2.32) | 29.9 (7.59) | 54.4 (9.43) | 54.4 (6.77) | 0.004 |
Blood urea nitrogen, mmol/L | 5.70 (0.37) | 7.46 (1.21) | 11.3 (1.51) | 7.62 (1.08) | 0.002 |
Creatinine, μmol/L | 70.0 (2.00) | 66.2 (6.53) | 107.2 (8.12) | 81.6 (5.83) | < 0.001 |
Lactate dehydrogenase, U/L | 226 (9.08) | 216 (29.1) | 485 (36.2) | 387 (26.0) | < 0.001 |
Albumin, g/L | 34.8 (0.44) | 34.6 (1.44) | 31.0 (1.79) | 30.3 (1.28) | 0.004 |
Total cholesterol, mmol/L | 4.63 (0.09) | 4.97 (0.29) | 4.04 (0.33) | 3.95 (0.24) | 0.012 |
Triglyceride, mmol/L | 1.72 (0.07) | 1.62 (0.23) | 1.58 (0.26) | 1.53 (0.19) | 0.802 |
HDL-C, mmol/L | 1.11 (0.03) | 1.12 (0.08) | 0.94 (0.10) | 0.93 (0.07) | 0.050 |
LDL-C mmol/L | 2.74 (0.07) | 3.09 (0.24) | 2.32 (0.27) | 2.20 (0.20) | 0.014 |
Cystatin C, mg/L | 0.93 (0.13) | 2.44 (0.42) | 1.32 (0.52) | 1.12 (0.37) | 0.008 |
Fasting glucose, mmol/L | 6.25 (0.19) | 6.01 (0.61) | 8.85 (0.76) | 8.69 (0.54) | < 0.001 |
Procalcitonin, ng/ml | 0.11 (0.16) | 0.10 (0.55) | 3.04 (0.69) | 1.12 (0.49) | < 0.001 |
BNP, pg/ml | 76.8 (26.7) | 201.2 (64.2) | 100.9 (61.3) | 120.4 (54.2) | 0.349 |
Cardiac Troponin I, ng/l | 10.4 (25.7) | 4.66 (77.0) | 39.2 (98.4) | 220.6 (66.0) | 0.038 |
CKMB mass, ng/ml | 0.85 (0.17) | 1.81 (0.51) | 2.85 (0.62) | 2.55 (0.43) | < 0.001 |
CKMB activity, U/L | 12.8 (0.84) | 13.7 (2.73) | 16.3 (3.54) | 17.7 (2.53) | 0.286 |
FT3, pmol/L | 4.20 (0.05) | 4.33 (0.16) | 2.44 (0.20) | 2.20 (0.14) | < 0.001 |
FT4, pmol/L | 13.0 (0.13) | 12.7 (0.42) | 12.6 (0.52) | 11.9 (0.37) | 0.047 |
THS, μIU/ml | 2.08 (0.08) | 7.06 (0.27) | 0.13 (0.33) | 1.26 (0.24) | < 0.001 |