Skip to main content

Table 2 Laboratory measurements according to different thyroid function categories among patients with COVID-19

From: Suppression of the hypothalamic-pituitary-thyroid axis is associated with the severity of prognosis in hospitalized patients with COVID-19

  NTF Subclinical hypothyroidism Severe NTIS Mild to moderate NTIS P values
No. of participants 184 17 11 23  
White blood cell count, ×109/L 6.26 (0.20) 6.52 (0.66) 9.33 (0.81) 7.59 (0.59) 0.001
Neutrophil count, ×109/L 4.23 (0.19) 4.41 (0.60) 8.14 (0.75) 6.22 (0.54) < 0.001
Lymphocyte count, ×109/L 1.50 (0.07) 1.48 (0.21) 0.71 (0.27) 0.88 (0.19) 0.002
CRP, mg/L 17.6 (2.59) 7.65 (8.25) 82.0 (10.3) 67.4 (7.37) < 0.001
Prothrombin time, s 13.0 (0.30) 13.0 (0.99) 17.8 (1.16) 13.9 (0.90) 0.001
ESR, mm/h 43.9 (2.73) 31.0 (9.23) 55.3 (13.8) 81.5 (8.50) < 0.001
APTT, s 39.7 (2.26) 35.1 (7.61) 39.8 (8.91) 44.3 (6.88) 0.843
D-Dimer > 0.5 mg/L, % 57 (38.0) 8 (72.7) 5 (62.5) 14 (77.8) 0.001
Fibrinogen, g 3.79 (0.08) 3.29 (0.27) 4.72 (0.32) 3.88 (0.25) 0.009
Thrombin time, s 16.4 (0.71) 15.4 (2.40) 16.5 (2.81) 16.3 (2.17) 0.982
ALT, U/L 43.1 (2.46) 33.4 (8.05) 46.7 (10.0) 45.8 (7.18) 0.631
AST, U/L 32.5 (2.32) 29.9 (7.59) 54.4 (9.43) 54.4 (6.77) 0.004
Blood urea nitrogen, mmol/L 5.70 (0.37) 7.46 (1.21) 11.3 (1.51) 7.62 (1.08) 0.002
Creatinine, μmol/L 70.0 (2.00) 66.2 (6.53) 107.2 (8.12) 81.6 (5.83) < 0.001
Lactate dehydrogenase, U/L 226 (9.08) 216 (29.1) 485 (36.2) 387 (26.0) < 0.001
Albumin, g/L 34.8 (0.44) 34.6 (1.44) 31.0 (1.79) 30.3 (1.28) 0.004
Total cholesterol, mmol/L 4.63 (0.09) 4.97 (0.29) 4.04 (0.33) 3.95 (0.24) 0.012
Triglyceride, mmol/L 1.72 (0.07) 1.62 (0.23) 1.58 (0.26) 1.53 (0.19) 0.802
HDL-C, mmol/L 1.11 (0.03) 1.12 (0.08) 0.94 (0.10) 0.93 (0.07) 0.050
LDL-C mmol/L 2.74 (0.07) 3.09 (0.24) 2.32 (0.27) 2.20 (0.20) 0.014
Cystatin C, mg/L 0.93 (0.13) 2.44 (0.42) 1.32 (0.52) 1.12 (0.37) 0.008
Fasting glucose, mmol/L 6.25 (0.19) 6.01 (0.61) 8.85 (0.76) 8.69 (0.54) < 0.001
Procalcitonin, ng/ml 0.11 (0.16) 0.10 (0.55) 3.04 (0.69) 1.12 (0.49) < 0.001
BNP, pg/ml 76.8 (26.7) 201.2 (64.2) 100.9 (61.3) 120.4 (54.2) 0.349
Cardiac Troponin I, ng/l 10.4 (25.7) 4.66 (77.0) 39.2 (98.4) 220.6 (66.0) 0.038
CKMB mass, ng/ml 0.85 (0.17) 1.81 (0.51) 2.85 (0.62) 2.55 (0.43) < 0.001
CKMB activity, U/L 12.8 (0.84) 13.7 (2.73) 16.3 (3.54) 17.7 (2.53) 0.286
FT3, pmol/L 4.20 (0.05) 4.33 (0.16) 2.44 (0.20) 2.20 (0.14) < 0.001
FT4, pmol/L 13.0 (0.13) 12.7 (0.42) 12.6 (0.52) 11.9 (0.37) 0.047
THS, μIU/ml 2.08 (0.08) 7.06 (0.27) 0.13 (0.33) 1.26 (0.24) < 0.001
  1. Data are means (SE) and are adjusted for age and sex unless otherwise indicated percentages. Abbreviations: COVID-19 coronavirus disease 2019, NTF Normal thyroid function, NTIS Non-thyroidal illness syndrome, CRP C-reactive protein, ESR Erythrocyte sedimentation rate, APTT Activation of partial thromboplastin time, ALT Alanine aminotransferase, AST, Aspartate aminotransferase, HDL-C High-density lipoprotein cholesterol, LDL-C Low-density lipoprotein cholesterol, BNP B-type natriuretic peptide, FT3 Free Triiodothyronine, FT4 Free Thyroxine, TSH Thyroid-stimulating hormone