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Table 2 Laboratory measurements according to different thyroid function categories among patients with COVID-19

From: Suppression of the hypothalamic-pituitary-thyroid axis is associated with the severity of prognosis in hospitalized patients with COVID-19

 

NTF

Subclinical hypothyroidism

Severe NTIS

Mild to moderate NTIS

P values

No. of participants

184

17

11

23

 

White blood cell count, ×109/L

6.26 (0.20)

6.52 (0.66)

9.33 (0.81)

7.59 (0.59)

0.001

Neutrophil count, ×109/L

4.23 (0.19)

4.41 (0.60)

8.14 (0.75)

6.22 (0.54)

< 0.001

Lymphocyte count, ×109/L

1.50 (0.07)

1.48 (0.21)

0.71 (0.27)

0.88 (0.19)

0.002

CRP, mg/L

17.6 (2.59)

7.65 (8.25)

82.0 (10.3)

67.4 (7.37)

< 0.001

Prothrombin time, s

13.0 (0.30)

13.0 (0.99)

17.8 (1.16)

13.9 (0.90)

0.001

ESR, mm/h

43.9 (2.73)

31.0 (9.23)

55.3 (13.8)

81.5 (8.50)

< 0.001

APTT, s

39.7 (2.26)

35.1 (7.61)

39.8 (8.91)

44.3 (6.88)

0.843

D-Dimer > 0.5 mg/L, %

57 (38.0)

8 (72.7)

5 (62.5)

14 (77.8)

0.001

Fibrinogen, g

3.79 (0.08)

3.29 (0.27)

4.72 (0.32)

3.88 (0.25)

0.009

Thrombin time, s

16.4 (0.71)

15.4 (2.40)

16.5 (2.81)

16.3 (2.17)

0.982

ALT, U/L

43.1 (2.46)

33.4 (8.05)

46.7 (10.0)

45.8 (7.18)

0.631

AST, U/L

32.5 (2.32)

29.9 (7.59)

54.4 (9.43)

54.4 (6.77)

0.004

Blood urea nitrogen, mmol/L

5.70 (0.37)

7.46 (1.21)

11.3 (1.51)

7.62 (1.08)

0.002

Creatinine, μmol/L

70.0 (2.00)

66.2 (6.53)

107.2 (8.12)

81.6 (5.83)

< 0.001

Lactate dehydrogenase, U/L

226 (9.08)

216 (29.1)

485 (36.2)

387 (26.0)

< 0.001

Albumin, g/L

34.8 (0.44)

34.6 (1.44)

31.0 (1.79)

30.3 (1.28)

0.004

Total cholesterol, mmol/L

4.63 (0.09)

4.97 (0.29)

4.04 (0.33)

3.95 (0.24)

0.012

Triglyceride, mmol/L

1.72 (0.07)

1.62 (0.23)

1.58 (0.26)

1.53 (0.19)

0.802

HDL-C, mmol/L

1.11 (0.03)

1.12 (0.08)

0.94 (0.10)

0.93 (0.07)

0.050

LDL-C mmol/L

2.74 (0.07)

3.09 (0.24)

2.32 (0.27)

2.20 (0.20)

0.014

Cystatin C, mg/L

0.93 (0.13)

2.44 (0.42)

1.32 (0.52)

1.12 (0.37)

0.008

Fasting glucose, mmol/L

6.25 (0.19)

6.01 (0.61)

8.85 (0.76)

8.69 (0.54)

< 0.001

Procalcitonin, ng/ml

0.11 (0.16)

0.10 (0.55)

3.04 (0.69)

1.12 (0.49)

< 0.001

BNP, pg/ml

76.8 (26.7)

201.2 (64.2)

100.9 (61.3)

120.4 (54.2)

0.349

Cardiac Troponin I, ng/l

10.4 (25.7)

4.66 (77.0)

39.2 (98.4)

220.6 (66.0)

0.038

CKMB mass, ng/ml

0.85 (0.17)

1.81 (0.51)

2.85 (0.62)

2.55 (0.43)

< 0.001

CKMB activity, U/L

12.8 (0.84)

13.7 (2.73)

16.3 (3.54)

17.7 (2.53)

0.286

FT3, pmol/L

4.20 (0.05)

4.33 (0.16)

2.44 (0.20)

2.20 (0.14)

< 0.001

FT4, pmol/L

13.0 (0.13)

12.7 (0.42)

12.6 (0.52)

11.9 (0.37)

0.047

THS, μIU/ml

2.08 (0.08)

7.06 (0.27)

0.13 (0.33)

1.26 (0.24)

< 0.001

  1. Data are means (SE) and are adjusted for age and sex unless otherwise indicated percentages. Abbreviations: COVID-19 coronavirus disease 2019, NTF Normal thyroid function, NTIS Non-thyroidal illness syndrome, CRP C-reactive protein, ESR Erythrocyte sedimentation rate, APTT Activation of partial thromboplastin time, ALT Alanine aminotransferase, AST, Aspartate aminotransferase, HDL-C High-density lipoprotein cholesterol, LDL-C Low-density lipoprotein cholesterol, BNP B-type natriuretic peptide, FT3 Free Triiodothyronine, FT4 Free Thyroxine, TSH Thyroid-stimulating hormone
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