Fig. 2

Boxplots of HOMA-IR (A), IAI (B), QUICKI (C), ISImatsuda (D) and HOMA-β (E) in HG-KS group, HG group and NGT group. * represented significant difference (p<0.05) between two groups. HOMA-IR (A) (p = 0.032) was significantly increased in HG-KS group compared to NGT group, IAI (B) (p = 0.028), QUICKI (C) (p = 0.028) and ISImatsuda (D) (p = 0.009) was significantly decreased in HG-KS group compared to NGT. HOMA-β (E) was significantly increased in HG-KS group compared to both HG (p = 0.030) and NGT (p = 0.044) groups. Abbreviations: KS Klinefelter syndrome, HG hyperglycemia, NGT normal glucose tolerance, HOMA-IR homeostasis model assessment of insulin resistance, HOMA-β homeostasis model assessment of β -cell function, ISImatsuda insulin sensitivity index proposed by Matsuda et al., QUICKI quantitative insulin sensitivity check index, IAI insulin action index