Table 1 Demographic and clinical data (mean ± SD) / (n, %)

Number

16

60

60

136

27

62

43

23

128

291

–

–

Age (years)

27.19 ± 10.94

29.71 ± 7.70

26.62 ± 7.77

27.81 ± 8.62

27.41 ± 8.96

25.95 ± 5.71

28.91 ± 8.13

25.78 ± 7.29

26.91 ± 7.04

27.38 ± 8.01

1.366^a

0.409^b

0.241^a

0.665^b

 male

4 (25.00)

25 (41.67)

28 (46.67)

71 (52.21)

11 (40.74)

28 (45.16)

12 (27.91)

13 (56.52)

53 (41.41)

140 (48.11)

8.208^a

0.223^a

 female

12 (75.00)

35 (58.33)

32 (53.33)

65 (47.79)

16 (59.26)

34 (54.84)

31 (72.09)

10 (43.48)

75 (58.59)

151 (51.89)

4.563^b

0.102^b

 junior High school and below

8 (50.00)

40 (66.67)

20 (33.33)

68 (50.00)

15 (55.56)

32 (51.61)

23 (34.88)

11 (53.49)

66 (51.56)

149 (51.20)

18.442^a

0.413^b

0.103^a

0.981^b

 high school and technical secondary school

5 (31.25)

7 (11.67)

24 (40.00)

36 (26.47)

6 (22.22)

15 (24.19)

9 (39.53)

7 (20.93)

31 (24.22)

73 (25.09)

 bachelor degree or above

3 (18.75)

13 (21.67)

16 (26.67)

32 (23.53)

6 (22.22)

15 (24.19)

11 (25.58)

5 (25.58)

31 (24.22)

69 (23.71)

 unmarried

9 (56.25)

25 (41.67)

32 (53.33)

66 (48.53)

17 (62.96)

22 (35.48)

15 (34.88)

12 (52.17)

49 (38.28)

132 (45.36)

19.284^a

6.932^b

0.082^a

0.140^b

 married

6 (37.50)

27 (45.00)

24 (40.00)

57 (41.91)

8 (29.63)

34 (54.84)

22 (51.16)

5 (21.74)

61 (47.66)

126 (43.30)

 divorced or widowed

1 (6.25)

8 (13.33)

4 (6.67)

13 (9.56)

2 (7.41)

6 (9.68)

6 (13.95)

6 (26.09)

18 (14.06)

33 (11.34)

 on-the-job or student

14 (87.50)

40 (66.67)

32 (53.33)

86 (63.24)

14 (51.85)

41 (66.13)

32 (74.42)

16 (69.57)

69 (53.91)

169 (58.08)

11.189^a

3.390^b

0.083^a

0.184^b

 unemployment (including retirement)

2 (12.50)

20 (33.33)

28 (46.67)

50 (36.76)

13 (48.15)

21 (33.87)

11 (25.58)

7 (30.43)

59 (46.09)

122 (41.92)

 no

12 (75.00)

47 (78.33)

51 (85.00)

110 (80.88)

20 (59.26)

48 (77.42)

35 (81.40)

19 (82.61)

102 (79.69)

232 (79.73)

9.925^a

0.128^a

 yes

4 (25.00)

13 (21.67)

9 (15.00)

26 (19.12)

7 (40.74)

14 (22.58)

8 (18.60)

4 (17.39)

26 (20.31)

59 (22.61)

0.192^b

0.996^b

Total disease course (years)

6.44 ± 5.85

6.87 ± 4.81

5.57 ± 4.74

6.42 ± 4.96

6.22 ± 4.93

7.60 ± 4.14

7.30 ± 5.98

5.87 ± 4.63

7.19 ± 4.96

6.66 ± 4.98

1.121^a

1.300^b

0.350^a

0.274^b

MADRS

–

–

–

–

26.54 ± 6.72

23.00 ± 10.70

32.48 ± 9.31

31.11 ± 6.17

25.74 ± 11.79

–

–

–

YMRS

15.75 ± 8.78

29.39 ± 10.00

31.45 ± 12.29

28.57 ± 12.00

21.60 ± 7.62

–

–

–

–

–

–

–

 TSH (mU/L)

2.37 ± 1.14

2.38 ± 1.69

2.21 ± 1.43

2.31 ± 1.51

2.11 ± 1.07

2.30 ± 1.41

2.60 ± 1.87

1.73 ± 0.72

2.30 ± 1.51

2.29 ± 1.47

1.013^a

0.200^b

0.417^a

0.819^b

 TT3 (nmol/L)

1.41 ± 0.40

1.62 ± 0.56

2.18 ± 2.74

1.86 ± 1.92

1.53 ± 0.37

1.55 ± 0.40

1.39 ± 0.47

1.59 ± 0.31

1.50 ± 0.40

1.66 ± 1.32

2.043^a

2.514^b

0.060^a

0.083^b

 FT3 (pmol/L)

4.51 ± 1.20

9.67 ± 18.25

7.12 ± 12.51

8.10 ± 15.05

4.69 ± 1.12

4.32 ± 1.13

4.00 ± 1.34

4.62 ± 1.05

4.26 ± 1.20

6.03 ± 10.23

2.139^a

4.804^b

0.049^a

0.009^b

 TT4 (nmol/L)

64.83 ± 37.16

69.27 ± 53.03

69.07 ± 41.25

68.84 ± 46.50

79.17 ± 34.25

76.82 ± 29.27

66.27 ± 34.08

78.97 ± 37.06

73.66 ± 32.59

71.88 ± 39.45

0.719^a

0.965^b

0.635^a

0.382^b

 FT4 (pmol/L)

13.34 ± 5.97

12.92 ± 6.73

13.64 ± 6.32

13.28 ± 6.45

14.07 ± 6.29

14.98 ± 10.27

11.69 ± 6.35

14.19 ± 3.55

13.73 ± 8.27

13.60 ± 7.23

0.998^a

0.195^b

0.427^a

0.823^b