Fig. 4
From: The genomic profiling and MAMLD1 expression in human and canines with Cushing’s disease
Boxplot comparison of overexpressed genes in humans and dogs. Average comparisons and standard deviations are shown for human corticotroph pituitary adenomas (HC PA, n = 6) and human normal pituitary (HN, n = 2). Median comparisons and standard deviations are shown for dog corticotroph pituitary adenomas (DC PA, n = 7) and dog normal pituitary (DN, n = 6). Normalized FPKM levels for 14 overexpressed genes in corticotroph PA (red) and normal pituitary (blue) are shown for humans (A), and dogs (B). MAMLD1, MNX1, RASEF, TBX19, BIRC5, TK1, GLDC, and FAM131B were significantly overexpressed in corticotroph PA as compared to normal pituitary (P < 0.05) in both humans and dogs. AVPR1B and FZD9 were significantly (P < 0.05) overexpressed in only human PA. POMC, and CEP55 were significantly (P < 0.05) overexpressed in only dog PA