The susceptibility of SERPINE1 rs1799889 SNP in diabetic vascular complications: a meta-analysis of fifty-one case-control studies

Table 5 Overall and subgroup meta-analysis of the association between SERPINE1 rs1799889 SNP and risk of diabetic nephropathy

Categories	n	4G vs. 5G			4G4G vs. 5G5G			4G5G vs. 5G5G			4G4G + 4G5G vs. 5G5G			4G4G vs. 5G5G + 5G4G
Categories	n	OR (95 %CI)	P	I² (%)/ Ph	OR (95 %CI)	P0.00	I² (%)/ Ph0.00/0.00	OR(95 %CI)	P	I² (%)/ Ph	OR(95 %CI)	P	I² (%)/ Ph	OR(95 %CI)	P	I² (%)/ Ph
Overall	15	1.48 (REM)(1.15–1.90)	0.001	83 %/0.001	1.92 (REM)(1.26–2.95)	0.001	74 %/0.001	1.13 (REM)(0.83–1.53)	0.43	58 %/0.001	1.41 (REM)(1.01–1.97)	0.04	70 %/0.001	1.78 (REM)(1.27–2.51)	0.001	77 %/0.001
Subgroup (by population)
European	3	1.06(0.91–1.24)	0.45	0 %/0.82	1.16(0.84–1.60)	0.37	0 %/0.90	1.17(0.88–1.57)	0.28	38 %/0.20	1.16(0.88–1.53)	0.28	0 %/0.59	1.04(0.74–1.46)	0.84	46 %/0.15
Asian	11	1.70 (REM)(1.17–2.47)	0.01	84 %/0.001	2.46 (REM)(1.30–4.66)	0.01	76 %/0.001	1.15 (REM)(0.71–1.86)	0.56	65 %/0.001	1.59 (REM)(0.94–2.69)	0.08	75 %/0.001	2.24 (REM)(1.40–3.59)	0.001	75 %/0.001
Others	1	1.12(0.86–1.47)	0.40	N/A	1.25(0.73–2.14)	0.41	N/A	0.88(0.55–1.41)	0.59	N/A	0.99(0.64–1.55)	0.98	N/A	1.36(0.88–2.11)	0.16	N/A

n: study numbers, OR: odds ratio, CI: confidence interval, bold values represent statistically significant findings, Ph: P heterogeneity (P < 0.1 was considered as a significant difference), REM: Random Effects Model

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