Table 2 Unadjusted and multiple adjusted hazard ratios of incident CKD by cut off value of 11 years for the duration of EEE and subgroups of age at baseline
From: Endogenous estrogen exposure and chronic kidney disease; a 15-year prospective cohort study
Endogenous estrogen exposure duration | Crude number of incident CKD (incident rate per 1000 person years) (95% CI) | Unadjusted | Adjusted* | ||
|---|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | ||
Total | |||||
N = 3043 | |||||
 Group1 (< 11 years) | 769 (53.9) | 1.17 (1.1,1.3) | 0.002 | 4.0 (2.5,6.3) | < 0.001 |
 N = 1429 | (50.2,57.8) | ||||
 Group 2 (≥11 years) | 829 (47.1) | Ref | Ref | Ref | Ref |
 N = 1614 | (44.0,50.4) | ||||
< 45 years | |||||
N = 1860 | |||||
 Group1 (< 11 years) | 537 (45.6) | 2.2 (1.9,2.5) | < 0.001 | 2.7 (2.2,3.2) | < 0.001 |
 N = 1120 | (41.9,49.7) | ||||
 Group 2 (≥11 years) | 222 (22.4) | Ref | Ref | Ref | Ref |
 N = 740 | (19.6,25.5) | ||||
≥45 years | |||||
N = 1183 | |||||
 Group1(< 11 years) | 232 (92.5) | 1.17 (1.0,1.4) | 0.03 | 1.22 (1.04,1.4) | 0.01 |
 N = 309 | (81.3105.2) | ||||
 Group 2 (≥11 years) | 607 (78.9) | Ref | Ref | Ref | Ref |
 N = 874 | (72.9,85.5) | ||||