Table 1 Study variables

Demographic data (2)

• Sex

• Age at the onset of hyperthyroidism

Characteristics of hyperthyroidism course (11)

• Thyroid function:

▪ thyroid-stimulating hormone level

▪ free triiodthyronine level

▪ free tetraiodthyronine level

• Thyroid-stimulating hormone receptors antibodies level (only in subjects with Graves’ disease)

• Hyperthyroidism duration (for patients with AF - before AF development), months

• Subclinical hyperthyroidism duration (more/less than year)

• The periods of hypothyroidism (absence/presence)

• The relapses of hyperthyroidism (the number of relapses)

• Weight loss at the onset of hyperthyroidism (during first 1–6 months)

• Hyperthyroidism genesis (Graves’ disease, toxic adenoma, multinodular toxic goiter)

• Extrathyroidal Graves’ disease manifestations (ophthalmopathy, pretibial myxedema)

Metabolic parameters, smoking status and blood tests during hyperthyroidism (11)

• Body mass index

• Carbohydrate metabolism disorders (diabetes mellitus, impaired fasting glucose, impaired glucose tolerance)

• Lipid panel:

▪ Total cholesterol

▪ Triglycerides

▪ High density lipoproteins

▪ Low density lipoproteins

• Smoking history

• Potassium serum level

• Hemoglobin level

• Renal function:

▪ Serum creatinine concentration

▪ Estimated glomerular filtration rate

Initial cardiovascular status (4)

• Arterial hypertension (absence/presence, target ABP/ABP above target)

• Coronary heart disease (absence/presence, a prior history of myocardial infarction)

• Rhythm disorders (premature atrial and ventricular contraction, supraventricular and non-sustained ventricular tachycardia, wandering of atrial pacemaker)

• Congestive heart failure (absence/presence)

Cardiovascular status during hyperthyroidism

(6)

• Arterial hypertension (absence/presence, target ABP/ above target ABP)

• Heart rate (recorded during physical examination, conducted in the period of overt hyperthyroidism before the therapy initiation), beat per minute

• Rhythm disorders:

▪ premature atrial contraction

▪ premature ventricular contraction

▪ other: supraventricular and non-sustained ventricular tachycardia, wandering of atrial pacemaker

• Congestive heart failure (absence/presence)

Heart rate-reducing therapy (2)

• Heart rate-reducing therapy before hyperthyroidism

• Heart rate-reducing therapy during hyperthyroidism