Table 2 Reproductive endocrine parameters in women with prior menstrual disorders and controls before and after HRT
Variable | Perimenopausal | Postmenopausal | ||||
|---|---|---|---|---|---|---|
Normal menstruation (N = 410) | Menstrual disorders (N = 46) | P valuea | Normal menstruation (N = 120) | Menstrual disorders (N = 19) | P valuea | |
E2 (pmol/L) | ||||||
 Before HRT | 63 (28.46, 139.18) | 43.52 (18.35, 110.13) | 0.11 | 43.31 (18.35, 76.81) | 38.24 (18.40, 57.49) | 0.45 |
 After HRT | 195.95 (121.43, 309.67) | 205.50 (129.50,440.70) | 0.24 | 166.60 (90.67, 248.89) | 98.92 (45.80, 153.00) | 0.05 |
P valueb | 0.000 | 0.000 | Â | 0.000 | 0.02 | Â |
 Δ E2†(pmol/L) | 118.89 (11.23, 228.34) | 164.63 (38.43, 361.75) | 0.12 | 89.13 (27.49, 176.74) | 55.61 (0.00, 112.65) | 0.19 |
FSH (IU/L) | ||||||
 Before HRT | 69.50 (51.81, 89.60) | 69.30 (55.22, 98.60) | 0.37 | 76.73 ± 28.85 | 74.22 ± 35.02 | 0.73 |
 After HRT | 43.00 (27.68, 62.46) | 43.64 (23.87, 58.39) | 0.82 | 53.86 ± 27.01 | 54.93 ± 25.76 | 0.87 |
P valueb | 0.000 | 0.000 | Â | 0.000 | 0.005 | Â |
 Δ FSH†(IU/L) | −23.51(−43.71, −5.51) | −28.00(−45.20, −16.01) | 0.19 | −22.87 ± 25.45 | −19.30 ± 25.95 | 0.57 |
LH (IU/L) | ||||||
 Before HRT | 37.74 (28.80, 48.57) | 39.17 (29.32, 50.67) | 0.54 | 35.19 (27.99, 45.96) | 35.03 (24.38, 43.38) | 0.76 |
 After HRT | 29.04 (18.48, 39.66) | 30.27 (18.74, 41.85) | 0.55 | 30.59 (20.89, 39.74) | 31.90 (17.73, 40.77) | 0.94 |
P valueb | 0.000 | 0.001 | Â | 0.000 | 0.09 | Â |
 Δ LH†(IU/L) | −9.09 ± 17.11 | −8.61 ± 17.05 | 0.86 | −6.86(−12.85, 2.81) | −2.61(−9.73, 4.50) | 0.46 |