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Table 4 Results of crude and adjusted linear regression analysis for the time to pregnancy, number of abortions & parity by thyroid function and TPOAb status

From: The association between subclinical hypothyroidism and TPOAb positivity with infertility in a population-based study: Tehran thyroid study (TTS)

Exposure (time to pregnancy) Coefficient (95%CI) * P_value
Crude models
 FT4 (ng/dl) −0.890 (−4.168–2.388) −0.594
 TSH (mU/L) 0.086 (−0.167–0.340) 0.505
 TPOAb (IU/ml) −0.00 (− 0.006–0.006) 0.891
 TPOAb Positive 0.64 (−2.1, 3.4) 0.648  
Negative (ref)  
Adjusted model 1#
 FT4 (ng/dl) −0.768 (−4.118–2.592) 0.644
 TSH (mU/L) 0.079 (−0.175–0.333) 0.543
 TPOAb (IU/ml) −0.00 (− 0.006–0.006) 0.958
 TPOAb Positive 0.56 (−2.1, 3.3) 0.688
Negative (ref)  
Adjusted model 2##
 FT4 (ng/dl) −0.759 (−4.109–2.592) 0.657
 TSH (mU/L) 0.087 (−0.168–0.343) 0.502
 TPOAb (IU/ml) −0.00 (− 0.006–0.006) 0.986
 TPOAb Positive 0.56 (−2.1, 3.3) 0.688
Negative (ref)  
Exposure number of Abortion The coefficient (95%CI) P_value
Crude models
 FT4 (ng/dl) −0.182 (−0.368–0.005) 0.057
 TSH (mU/L) 0.00(−0.014–0.015) 0.969
 TPOAb (IU/ml) 0.00 (0.00–0.00) 0.788
 TPOAb Positive 0.03 (−.15, .20) 0.775
Negative (ref)  
Adjusted model 1#
 FT4 (ng/dl) −0.058 (−0.246–0.130) 0.544
 TSH (mU/L) 0.005 (−0.010–0.019) 0.526
 TPOAb (IU/ml) 0.00 (0.00–0.00) 0.822
 TPOAb Positive 0.03 (−.15, .20) 0.744
Negative (ref)  
Adjusted model 2##
 FT4 (ng/dl) −0.043 (−0.232–0.146) 0.657
 TSH (mU/L) 0.004 (−0.010–0.018) 0.592
 TPOAb 0.00 (0.00–0.00) 0.785
 TPOAb Positive 0.03 (−.15, .20) 0.744
Negative (ref)  
Exposures Coefficient for Parity(95%CI) P_value
Crude mode
 FT4(ng/dl) −0.634 (−0.863 – − 0.405) 0.000*
 TSH (mU/L) −0.010 (− 0.027–0.008) 0.291
 TPOAb (IU/ml) 0.00 (0.00–0.00) 0.891
 TPOAb Positive − 0.2 (−.18, .14) 0.830
Negative (ref)  
Adjusted model 1#
 FT4 (ng/dl) −0.103 (− 0.298–0.93) 0.304
 TSH (mU/L) 0.005 (− 0.010–0.020) 0.528
 TPOAb 0.00 (0.00–0.00) 0.988
 TPOAb Positive − 0.02 (−.16, .11) 0.672
Negative (ref)  
Adjusted model 2#
 FT4(ng/dl) −0.089 (− 0.283–0.106) 0.371
 TSH (mU/L) 0.006 (− 0.009–0.021) 0.414
 TPOAb (IU/ml) 0.00 (0.00–0.00) 0.968
 TPOAb Positive − 0.02 (−.16, .11) 0.672
Negative (ref)  
  1. *significant p-value < 0.05, # model adjusted for age, BMIand infertility status, ## model adjusted for age,education, BMI, fertility status,smoking, Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Fasting blood Sugar (FBS