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Table 4 Results of crude and adjusted linear regression analysis for the time to pregnancy, number of abortions & parity by thyroid function and TPOAb status

From: The association between subclinical hypothyroidism and TPOAb positivity with infertility in a population-based study: Tehran thyroid study (TTS)

Exposure (time to pregnancy)

Coefficient (95%CI)

* P_value

Crude models

 FT4 (ng/dl)

−0.890 (−4.168–2.388)

−0.594

 TSH (mU/L)

0.086 (−0.167–0.340)

0.505

 TPOAb (IU/ml)

−0.00 (− 0.006–0.006)

0.891

 TPOAb

Positive

0.64 (−2.1, 3.4) 0.648

 

Negative

(ref)

 

Adjusted model 1#

 FT4 (ng/dl)

−0.768 (−4.118–2.592)

0.644

 TSH (mU/L)

0.079 (−0.175–0.333)

0.543

 TPOAb (IU/ml)

−0.00 (− 0.006–0.006)

0.958

 TPOAb

Positive

0.56 (−2.1, 3.3)

0.688

Negative

(ref)

 

Adjusted model 2##

 FT4 (ng/dl)

−0.759 (−4.109–2.592)

0.657

 TSH (mU/L)

0.087 (−0.168–0.343)

0.502

 TPOAb (IU/ml)

−0.00 (− 0.006–0.006)

0.986

 TPOAb

Positive

0.56 (−2.1, 3.3)

0.688

Negative

(ref)

 

Exposure number of Abortion

The coefficient (95%CI)

P_value

Crude models

 FT4 (ng/dl)

−0.182 (−0.368–0.005)

0.057

 TSH (mU/L)

0.00(−0.014–0.015)

0.969

 TPOAb (IU/ml)

0.00 (0.00–0.00)

0.788

 TPOAb

Positive

0.03 (−.15, .20)

0.775

Negative

(ref)

 

Adjusted model 1#

 FT4 (ng/dl)

−0.058 (−0.246–0.130)

0.544

 TSH (mU/L)

0.005 (−0.010–0.019)

0.526

 TPOAb (IU/ml)

0.00 (0.00–0.00)

0.822

 TPOAb

Positive

0.03 (−.15, .20)

0.744

Negative

(ref)

 

Adjusted model 2##

 FT4 (ng/dl)

−0.043 (−0.232–0.146)

0.657

 TSH (mU/L)

0.004 (−0.010–0.018)

0.592

 TPOAb

0.00 (0.00–0.00)

0.785

 TPOAb

Positive

0.03 (−.15, .20)

0.744

Negative

(ref)

 

Exposures

Coefficient for Parity(95%CI)

P_value

Crude mode

 FT4(ng/dl)

−0.634 (−0.863 – − 0.405)

0.000*

 TSH (mU/L)

−0.010 (− 0.027–0.008)

0.291

 TPOAb (IU/ml)

0.00 (0.00–0.00)

0.891

 TPOAb

Positive

− 0.2 (−.18, .14)

0.830

Negative

(ref)

 

Adjusted model 1#

 FT4 (ng/dl)

−0.103 (− 0.298–0.93)

0.304

 TSH (mU/L)

0.005 (− 0.010–0.020)

0.528

 TPOAb

0.00 (0.00–0.00)

0.988

 TPOAb

Positive

− 0.02 (−.16, .11)

0.672

Negative

(ref)

 

Adjusted model 2#

 FT4(ng/dl)

−0.089 (− 0.283–0.106)

0.371

 TSH (mU/L)

0.006 (− 0.009–0.021)

0.414

 TPOAb (IU/ml)

0.00 (0.00–0.00)

0.968

 TPOAb

Positive

− 0.02 (−.16, .11)

0.672

Negative

(ref)

 
  1. *significant p-value < 0.05, # model adjusted for age, BMIand infertility status, ## model adjusted for age,education, BMI, fertility status,smoking, Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Fasting blood Sugar (FBS