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Table 5 Multivariate Cox Regression of All-Cause Mortality

From: Glycemic and lipid variability for predicting complications and mortality in diabetes mellitus using machine learning

Predictor Hazard Ratio (HR) 95% Confidence Interval (CI) P-Value
Age 1.04 [1.03, 1.04] < 0.0001
Male 1.18 [1.11, 1.27] < 0.0001
Diabetes Duration 0.956 [0.943, 0.970] < 0.0001
HbA1c
 Mean 1.09 [1.04, 1.15] < 0.001
 Standard Deviation 1.10 [0.825, 1.47] 0.511
 Coefficient of Variation 0.998 [0.973, 1.02] 0.869
Total Cholesterol (TC)
 Mean 1.14 [0.994, 1.30] 0.061
 Standard Deviation 0.787 [0.501, 1.24] 0.299
 Coefficient of Variation 1.02 [1.00, 1.05] 0.050
High Density Lipoprotein-Cholesterol (HDL-C)
 Mean 0.603 [0.513, 0.708] < 0.0001
 Standard Deviation 2.19 [1.52, 3.14] < 0.0001
Low Density Lipoprotein-Cholesterol
 Mean 0.916 [0.811, 1.03] 0.157
 Standard Deviation 1.19 [0.866, 1.64] 0.281
 Coefficient of Variation 0.992 [0.983, 1.00] 0.062
Triglyceride (TG)
 Baseline 0.996 [0.979, 1.01] 0.694
 Mean 1.06 [0.993, 1.14] 0.080
 Standard Deviation 0.932 [0.851, 1.02] 0.126
 Coefficient of Variation 0.998 [0.995, 1.00] 0.190
Other Tests
 Baseline Neutrophil-Lymphocyte Ratio 1.01 [1.01, 1.02] < 0.001
 Baseline Hemoglobin Count 0.911 [0.889, 0.934] < 0.0001
 Baseline Anemia 1.08 [0.981, 1.19] 0.119
 Hypoglycemia Frequency 1.03 [1.01, 1.05] 0.002
Anti-Diabetic Agent
 Sulphonylurea 1.08 [1.02, 1.16] 0.015
 Biguanide 0.616 [0.575, 0.660] < 0.0001
 Dipeptidyl peptidase-4 Inhibitor 0.706 [0.424, 1.18] 0.181
 Thiazolidinedione 0.885 [0.761, 1.03] 0.110