Up-regulation of sex-determining region Y-box 9 (SOX9) in growth hormone-secreting pituitary adenomas

BMC Endocrine Disorders

Table 6 The immunohistochemistry results of SOX9 protein evaluation in patients with GH-producing pituitary adenoma

Groups	Expression pattern ^a							P value
	Total number	Score 0		Score 1+		Score 2+
	Total number	N %		N %		N %
GH-producing pituitary tumors	40	10	25%	8	20%	22	55%
Macro adenoma	30	0	0	8	26.66%	22	73.33%	< 0.0001
Micro adenoma	10	7	70%	3	30%	0	0	< 0.0001
Invasive tumors	14	0	0	2	14.28%	12	85.71%	0.009
Non-invasive tumors	26	10	38.46%	6	23.07%	10	38.46%	0.009

^a The Expression pattern was determined based on the staining intensity of SOX9 antibody that is described in material and methods

ISSN: 1472-6823