Table 5 Topology table for up and down regulated genes

Up

CEBPD

114

0.046829

7961100

0.330434

Up

TP73

111

0.034635

8777680

0.328559

Up

ESR2

101

0.034485

6488550

0.337342

Up

TAB1

99

0.041885

3759452

0.362813

Up

MAP 3K5

92

0.030461

6831818

0.331998

Up

CACNA1A

91

0.035636

5405420

0.325712

Up

CCNA1

80

0.02152

6576136

0.326587

Up

SLC9A3R1

77

0.024066

3777376

0.332877

Up

SREBF1

70

0.01966

4888424

0.327673

Up

TGM2

69

0.023349

3331196

0.360768

Up

VAMP2

59

0.021393

4433628

0.327614

Up

FASN

57

0.012258

2145144

0.352708

Up

PSEN2

53

0.018322

2705190

0.32389

Up

CKB

51

0.012369

2056678

0.335511

Up

ALK

51

0.013768

1544390

0.292392

Up

MED16

46

0.014057

2049900

0.326909

Up

SLC9A3R2

45

0.013157

2184316

0.317821

Up

APOB

43

0.012557

2206980

0.322002

Up

MYOC

42

0.012184

1022522

0.322658

Up

IRAK2

41

0.012813

1784830

0.321293

Up

SLC2A4

40

0.011976

1766080

0.322601

Up

USHBP1

36

0.015448

3575428

0.248925

Up

MRPL11

34

0.010599

1753194

0.322287

Up

CPLX1

33

0.009034

742112

0.287437

Up

PACSIN1

33

0.010298

664252

0.278015

Up

PCBD2

32

0.010339

2852002

0.275204

Up

SLC25A10

30

0.009439

1406902

0.31647

Up

DOT1L

29

0.007619

3660752

0.26943

Up

CDK20

28

0.007513

1387276

0.314207

Up

ACAT2

28

0.007324

722288

0.326091

Up

CDKN2C

28

0.006528

1250162

0.316004

Up

CISH

27

0.005203

494888

0.295879

Up

GINS3

27

0.00745

1311612

0.3176

Up

MVD

26

0.008346

1085242

0.313613

Up

NR1I3

24

0.004449

1369088

0.285591

Up

RAC3

23

0.005847

909650

0.317324

Up

SETD1A

22

0.006802

741452

0.319296

Up

GLUL

21

0.006551

455932

0.338689

Up

NFKBIL1

20

0.007285

2695372

0.255984

Up

CD3EAP

19

0.004472

455916

0.289697

Up

SHANK2

19

0.00448

1859670

0.264621

Up

GPHN

18

0.005963

580752

0.315157

Up

PPP1R16A

17

0.006189

3748574

0.241315

Up

CYP2E1

17

0.00535

689500

0.318654

Up

IL12A

17

0.003913

940482

0.270248

Up

TAF1C

16

0.004869

576732

0.316965

Up

MPST

15

0.004427

490670

0.315703

Up

CNTFR

15

0.004392

3618160

0.24549

Up

DDR1

15

0.00321

479586

0.317379

Up

MKNK2

14

0.002033

289430

0.322116

Up

KCTD17

13

0.003492

916690

0.244208

Up

RGS3

13

0.001735

620256

0.320982

Up

SPHK1

13

0.002877

655002

0.317655

Up

PRPH

13

0.003388

599412

0.319436

Up

ADH1B

13

0.001294

370206

0.275682

Up

SLC25A22

13

0.003141

530858

0.314776

Up

MIB2

12

0.002205

375196

0.315185

Up

ZNF598

12

0.004687

393930

0.312779

Up

GK

12

0.003466

415618

0.314994

Up

RRAD

12

0.0025

148574

0.282166

Up

PFKFB3

12

0.001355

246878

0.314072

Up

SPTBN4

12

0.004741

379826

0.313909

Up

PTPN3

12

0.001814

952130

0.257957

Up

LIN7A

11

0.004011

512222

0.31796

Up

VPS37B

11

0.00232

329104

0.31372

Up

TRMT1L

11

0.002348

529928

0.319184

Up

EDNRA

11

0.001735

273128

0.314885

Up

TBC1D7

10

0.002122

358246

0.3176

Up

AZGP1

10

0.002218

255470

0.31337

Up

WDR62

10

0.001673

347176

0.314912

Up

NRXN1

10

0.003845

1972864

0.226227

Up

CLDN5

9

0.002871

301080

0.313343

Up

TYSND1

9

0.003301

1096284

0.204234

Up

NEK8

9

0.001286

501688

0.317158

Up

MICALL1

9

0.006015

346680

0.317103

Up

TNFRSF8

8

0.001683

558578

0.221218

Up

DDX11

8

0.002534

239432

0.313964

Up

CRHR1

8

0.002228

518378

0.23728

Up

QRICH2

8

0.002787

388592

0.238787

Up

TEAD4

8

0.002413

296338

0.312993

Up

CSPG4

8

0.001645

199988

0.313289

Up

CABP1

8

0.001378

82156

0.281578

Up

SULT1C2

8

0.001233

207860

0.315676

Up

GNG7

8

0.001801

266812

0.312779

Up

HADH

7

0.001386

314576

0.318043

Up

EBP

7

0.002552

384196

0.317186

Up

CSH1

7

8.48E-05

30798

0.243572

Up

C19orf25

7

0.001712

1024492

0.232753

Up

AASS

7

5.38E-04

163226

0.314804

Up

POLM

6

0.001104

522630

0.201203

Up

BSN

6

0.001531

145360

0.312457

Up

KIFC2

6

0.001203

58718

0.27345

Up

POMC

6

0.002233

811808

0.234609

Up

DCXR

6

0.001279

220510

0.31658

Up

EPHB4

6

8.00E-04

275102

0.317572

Up

RAB26

6

0.002046

260892

0.31658

Up

UBTD1

6

0.001963

183788

0.314586

Up

GNG3

6

8.77E-05

19382

0.228452

Up

SRCIN1

6

1.34E-04

36856

0.257593

Up

DLL1

6

0.001102

106292

0.313074

Up

IFI35

6

0.001499

178126

0.313666

Up

EPB41L4B

6

5.42E-04

276788

0.316497

Up

RDH13

5

0.001833

134020

0.312404

Up

SHROOM2

5

3.34E-05

23708

0.250636

Up

PGAM2

5

3.21E-04

99124

0.313101

Up

RASIP1

5

0.001351

121434

0.312404

Up

LDB3

5

5.77E-05

11670

0.240694

Up

STBD1

5

5.68E-04

91162

0.211163

Up

MYLPF

5

0.001107

295946

0.221057

Up

ZNF775

5

0.00111

426814

0.230721

Up

BOK

5

0.001655

134510

0.312404

Up

ARHGEF15

5

0.001681

719112

0.215939

Up

RRP1

5

6.51E-04

120052

0.314749

Up

LLGL2

5

0.001716

131528

0.312404

Up

PKN3

5

0.002193

149884

0.312404

Up

AATK

5

0.001114

414048

0.231497

Up

HELZ2

5

4.97E-04

113146

0.312752

Up

TPRN

4

5.53E-04

316590

0.229602

Up

PMM1

4

6.74E-04

50432

0.317324

Up

SCN4A

4

0.001101

106362

0.254501

Up

MIA

2

0

0

0.289951

Up

GCAT

1

0

0

0.265816

Up

CACNB2

1

0

0

0.241779

Up

PWWP2B

1

0

0

0.265816

Up

CEMP1

1

0

0

0.265816

Down

FN1

689

0.324012

1.05E+08

0.403385

Down

UBD

502

0.200346

87511340

0.362021

Down

RUNX1

96

0.029748

6112420

0.328351

Down

PIK3R2

91

0.025749

6760118

0.337529

Down

TNF

91

0.029868

5372816

0.339382

Down

TRIM63

88

0.033338

4601374

0.331545

Down

FASLG

83

0.03072

3652094

0.356361

Down

FLNC

77

0.027425

3582900

0.356257

Down

DAB2

63

0.01646

2823298

0.354974

Down

PRNP

61

0.022352

8130382

0.290089

Down

RUNX2

57

0.013307

3614466

0.32323

Down

UCHL1

54

0.013451

2855314

0.328973

Down

MAP 1B

45

0.011916

2421086

0.323574

Down

KRT14

44

0.006308

1848344

0.332361

Down

DYNC1I1

41

0.009986

4398264

0.2816

Down

UGP2

39

0.010629

2140698

0.318654

Down

KRT5

39

0.006255

1335540

0.352742

Down

THBS1

37

0.010831

751230

0.351315

Down

SULT1A1

36

0.010429

1425372

0.3207

Down

ITGAV

34

0.009907

738818

0.348595

Down

BLNK

34

0.006063

3165890

0.267709

Down

KRT16

34

0.004495

1291100

0.352231

Down

TUBB2B

34

0.006677

1049214

0.327997

Down

TPM2

31

0.005911

1029436

0.321832

Down

SERPINE1

31

0.006739

1233976

0.3258

Down

CSF1R

30

0.006717

1300016

0.330974

Down

TEC

29

0.006824

858984

0.329152

Down

UGDH

28

0.009574

1182896

0.320334

Down

EEA1

28

0.00918

1154334

0.31573

Down

CYBB

27

0.007148

1130954

0.315922

Down

SNCAIP

25

0.006301

1035622

0.319856

Down

HEXIM1

25

0.006057

1136892

0.320587

Down

PSAT1

24

0.005926

1376392

0.324034

Down

CASP6

23

0.005143

904188

0.326939

Down

CCND2

23

0.004537

916146

0.317683

Down

TFAP2C

23

0.0052

855498

0.321095

Down

C1QA

23

0.006243

387922

0.312967

Down

PDLIM1

22

0.005357

928252

0.314967

Down

FAM118B

22

0.008601

929084

0.314885

Down

MARCKS

22

0.00416

786398

0.318099

Down

KLF10

21

0.005139

897850

0.31669

Down

DACT1

20

0.00252

987976

0.277507

Down

LBP

20

0.004692

404246

0.288597

Down

AP1M2

20

0.005509

738138

0.318989

Down

ETV1

20

0.00302

609754

0.314315

Down

CACNA1C

19

0.004425

753630

0.318849

Down

F2R

19

0.005228

757806

0.314586

Down

WWC1

19

0.004648

1378328

0.261415

Down

SPARC

19

0.002419

271042

0.288871

Down

ETV5

19

0.006356

766338

0.321548

Down

HLA-DRB1

18

0.004301

753340

0.315922

Down

CD2

18

0.004823

668514

0.31658

Down

GTF2A1L

18

0.007186

2863798

0.23688

Down

GEM

17

0.005732

2326034

0.240583

Down

GNG2

16

0.003555

589398

0.314126

Down

IKBIP

16

0.004022

727254

0.319017

Down

METTL21C

15

0.003787

493576

0.315621

Down

ANKRD1

15

0.003619

472178

0.313774

Down

PTPRZ1

15

0.001661

140480

0.283902

Down

TRPV4

15

0.002549

481158

0.316662

Down

KCNA2

15

0.00436

1061814

0.239903

Down

ITGB1BP2

14

0.001989

240810

0.285502

Down

FSTL1

14

0.00427

2031070

0.23759

Down

CYP2C9

14

0.001662

302482

0.26514

Down

MTHFD1L

14

0.002585

651008

0.31647

Down

IQGAP2

13

0.002809

325554

0.314045

Down

PAG1

13

0.001736

135246

0.277571

Down

F13A1

13

0.001735

158432

0.30128

Down

FCGR2B

13

0.001066

801788

0.251639

Down

PALLD

13

0.003467

531744

0.313532

Down

CD28

13

0.00323

284756

0.32323

Down

RABIF

13

0.004967

429618

0.312832

Down

GRB14

12

0.002983

685690

0.249385

Down

LIMCH1

12

0.003625

2733430

0.254786

Down

FBN1

11

0.002676

383518

0.248755

Down

SAMSN1

11

8.53E-04

133970

0.288871

Down

EPHB3

11

0.003278

542624

0.316607

Down

ENC1

11

0.001583

423908

0.317324

Down

TRIM50

11

0.00292

496854

0.312886

Down

SERPINE2

11

0.002799

2273346

0.242664

Down

HLA-DQA1

11

0.002544

326930

0.314369

Down

ARRDC4

10

0.001535

375436

0.315157

Down

RND3

10

0.00448

330498

0.313182

Down

VLDLR

10

0.004556

320522

0.314804

Down

SOCS5

10

0.003457

380282

0.320869

Down

BAMBI

10

0.004199

323112

0.313909

Down

NAIP

9

0.003621

141406

0.276246

Down

DRD1

9

0.003299

1100044

0.229184

Down

GLB1

9

0.002193

292422

0.314858

Down

HGF

9

0.001854

1215984

0.238226

Down

ALX4

9

0.003365

1011538

0.2046

Down

COL3A1

9

5.70E-04

68058

0.284833

Down

MTF1

9

0.002252

733044

0.272103

Down

LOX

8

0.001541

584690

0.240345

Down

CACNG2

8

0.002377

668336

0.245242

Down

ANGPT2

8

8.97E-04

173688

0.314641

Down

INHBA

8

0.001672

81898

0.210214

Down

CCDC136

8

9.01E-04

360770

0.220509

Down

CCL18

8

0.001487

441826

0.255876

Down

PMEPA1

7

5.77E-04

135816

0.312967

Down

STAB1

7

0.001896

241374

0.264544

Down

KCNA1

7

6.54E-04

95830

0.211727

Down

CRABP2

7

4.03E-04

99166

0.313209

Down

PTGFRN

7

0.002199

667760

0.225681

Down

ASAH1

7

0.001266

221440

0.315457

Down

RCN3

7

0.00299

297670

0.314072

Down

FRZB

7

0.002208

481180

0.22015

Down

SLIT2

6

0.001658

181082

0.312967

Down

CLEC4M

6

0.001712

388848

0.245111

Down

TNFRSF12A

6

0.001027

142760

0.312671

Down

INSM1

6

0.001234

305024

0.249044

Down

SFRP2

6

6.16E-04

195012

0.229515

Down

SESN1

6

4.86E-04

138422

0.313801

Down

JAZF1

5

2.77E-04

135572

0.315922

Down

LINGO1

5

0.001129

296570

0.207901

Down

SLC5A1

5

5.97E-04

499752

0.26091

Down

SERF1A

5

4.54E-04

225474

0.3168

Down

TLR7

5

6.25E-04

167802

0.209634

Down

AMPD1

5

5.58E-04

409250

0.245374

Down

HPD

5

7.74E-04

98924

0.313936

Down

ICAM5

1

0

0

0.244667

Down

ADRA1B

1

0

0

0.262695