Table 3 The enriched GO terms of the up and down regulated differentially expressed genes

 GO:0034765

BP

regulation of ion transmembrane transport

2.49E-04

9.88E-02

8.85E-01

1.00E+00

21

KCNE5,RRAD,SLC9A3R2,SLC9A3R1,NRXN1,RAPGEF3,SCN4A,SHANK3,CRHR1,SHANK2,SPHK2,PSEN2,PTPN3,VAMP2,CACNA1A,KCNE2,CACNB2,TMC2,CASQ2,KCNK7,EDNRA

 GO:0043436

BP

oxoacid metabolic process

9.54E-04

1.64E-01

1.00E+00

1.00E+00

35

ACADS,ACAT2,GGT6,PFKFB3,PGAM2,ADH1B,CKB,FASN,PLIN5,MPST,SLC6A8,CSPG4,EGFLAM,PRODH,CYP2E1,SREBF1,GCK,ALDH1L1,TYSND1,ACSS2,ITIH1,LDHD,ADHFE1,GK,SULT1C2,SPHK1,GLUL,GPT2,CACNA1A,ANKRD23,MLXIPL,GCAT,AASS,HADH,DCXR

 GO:0031226

CC

intrinsic component of plasma membrane

3.56E-04

2.11E-02

1.44E-01

1.90E-01

48

EPHB4,HLA-DQA1,KCNE5,CD320,REEP2,NRXN1,SCN4A,NPC1L1,RAB26,ALK,CNTFR,ADCY4,ACVR1C,SHANK3,CRHR1,SLC2A4,SLC6A8,SHANK2,GPIHBP1,PLPP2,SLC26A7,CSPG4,EBP,FUT1,SLC4A4,SLC16A13,PSEN2,ADGRB3,FGFRL1,SLC30A3,SEMA4C,VAMP2,CA4,CACNA1A,KCNE2,DDR1,CACNB2,STBD1,TMC2,PCDHGC4,SLC19A3,SLC35G2,DLL1,EDA,KCNK7,SYT7,EDNRA,TGM2

 GO:0005739

CC

mitochondrion

2.66E-03

6.74E-02

4.62E-01

1.00E+00

46

HDHD3,ACADS,ACAT2,ESR2,GLYCTK,RDH13,YJEFN3,CKB,PCBD2,FASN,PLIN5,MPST,ADCK5,LGALS12,SLC25A10,MRPL11,PRODH,SPHK2,CYP2E1,MYOC,GCK,ALDH1L1,STOX1,ACSS2,POLR1G,LDHD,ADHFE1,GK,BOK,COQ8A,GLUL,PXMP2,MAIP1,GPT2,MGARP,TDRKH,DEPP1,ECHDC3,SLC25A22,TGM2,GCAT,AASS,SLC25A52,HADH,TMEM143,TP73

 GO:0016772

MF

transferase activity, transferring phosphorus-containing groups

1.80E-04

4.04E-02

2.98E-01

1.62E-01

52

CDK20,EPHB4,GPHN,CDKN2C,DAPK2,GLYCTK,CARD10,PFKFB3,PGAM2,MAP 3K5,CKB,CISH,SLC9A3R1,NRXN1,PI4KAP1,ALPK3,TAB1,ALK,MOCS1,PKN3,ANKK1,ADCY4,ADCK5,WNT11,ACVR1C,AATK,NEK8,CSPG4,PNCK,SPHK2,PSEN2,IRAK2,FGFRL1,GCK,STOX1,POLR1G,RASIP1,GK,COQ8A,SPHK1,CCNA1,GNG3,CCNJL,DDR1,POLM,MKNK2,WASHC1,SRCIN1,RGS3,EDNRA,MLXIPL,TP73

 GO:0005215

MF

transporter activity

2.72E-03

1.37E-01

1.00E+00

1.00E+00

40

KCNE5,RRAD,CD320,SLC9A3R1,NRXN1,RAPGEF3,SCN4A,NPC1L1,SVOP,APOB,SHROOM2,SHANK3,CRHR1,SLC2A4,SLC6A8,SHANK2,GPIHBP1,SLC26A7,EBP,SLC25A10,SLC4A4,SLC2A11,SPHK2,SLC16A13,AZGP1,CPLX1,SLC30A3,APOM,PTPN3,VAMP2,CACNA1A,KCNE2,CACNB2,TMC2,INAFM1,SLC19A3,TMEM63C,CASQ2,KCNK7,SLC25A22

 GO:0046649

BP

lymphocyte activation

1.37E-15

5.40E-12

4.78E-11

5.40E-12

40

HLA-DMB,HLA-DPA1,SPTA1,BCL11A,ITGA4,FGL2,CXCR5,FCRL1,PTPRC,ZC3H12D,FBXO7,CCR7,NOTCH2,TCF7,IKZF3,POLM,CAMK4,POU2F2,BTLA,CR1,CBLB,SLC4A1,TFRC,BCL11B,CD4,CD5,CD6,MS4A1,CD22,CD27,CD44,TNFRSF13C,TNFRSF13B,CD79A,RORA,ATM,LY9,LEF1,IL7R,NCKAP1L

 GO:0010941

BP

regulation of cell death

9.53E-05

6.03E-03

5.34E-02

3.75E-01

40

STK17B,OBSCN,ITGA4,NR4A1,STRADB,BNIP3L,PTPRC,BTG1,TMC8,FBXO7,PLAGL2,CCR7,NOTCH2,TCF7,IKZF3,OGT,CAMK1D,BMF,NLRP1,GRINA,OPA1,EEF1A1,TXNIP,BCL11B,IGF2R,CSF1R,CD27,NEURL1,CD44,LRP1,ATM,HBA1,HBA2,HBB,CTSB,LEF1,RPL10,IL7R,SORL1,NCKAP1L

 GO:0009986

CC

cell surface

2.02E-09

3.10E-07

2.08E-06

9.30E-07

35

ADAM19,HLA-DPA1,HLA-DRA,ITGA4,CXCR5,FCRL1,PTPRC,CIITA,MRC2,CCR7,NOTCH2,SEMA7A,BTLA,CR1,SLC4A1,TFRC,CD4,CD5,IGF2R,CD6,CSF1R,MS4A1,CLEC17A,CD22,CD27,GYPA,VCAN,CD44,CLEC2D,TNFRSF13C,TNFRSF13B,CD79A,LY9,CTSB,IL7R

 GO:0031226

CC

intrinsic component of plasma membrane

5.35E-07

4.11E-05

2.76E-04

2.47E-04

43

HLA-DPA1,HLA-DRA,SPTA1,SLC38A5,ITGA4,SLC38A1,CXCR5,PTPRC,SLC24A4,TMC8,NOTCH2,VIPR1,TRABD2A,SEMA7A,BTLA,SLC7A6,CR1,MCOLN1,SLC2A1,TSPAN5,RHAG,SLC4A1,TFRC,CELSR1,CD4,CD5,IGF2R,CD6,CSF1R,P2RX5,MS4A1,SLC14A1,CD22,CD27,GYPA,GYPB,CD44,CLEC2D,LRP1,TNFRSF13B,ATP2B1,SORL1,NCKAP1L

 GO:0016772

MF

transferase activity, transferring phosphorus-containing groups

9.72E-04

4.32E-02

3.09E-01

6.92E-01

35

ZBTB20,RPS6KA5,STK17B,OBSCN,TENT5C,TTN,PIK3IP1,BLK,STRADB,PTPRC,CIITA,FBXO7,CCR7,DYRK2,OGT,CAMK1D,CTC1,POLM,CAMK4,DUSP2,AAK1,CBLB,SLC4A1,EEF1A1,RMRP,CD4,IGF2R,CSF1R,NEURL1,CD44,LRP1,ATM,SERINC5,SORL1,NCKAP1L

 GO:0008144

MF

drug binding

1.15E-02

1.55E-01

1.00E+00

1.00E+00

30

ABCA2,RPS6KA5,STK17B,OBSCN,TTN,BLK,STRADB,CIITA,ALAS2,ABCD2,DYRK2,DNHD1,ACSL6,CAMK1D,EP400,ATP13A1,CAMK4,AAK1,NLRP1,EEF1A1,DNAH1,CSF1R,P2RX5,ATM,HBA1,HBA2,HBM,HBB,ATP2B1,EPB42