Lower normal free thyroxine is associated with a higher risk of metabolic syndrome: a retrospective cohort on Chinese population

Table 3 Comparison of the incidence of metabolic syndrome in different TSH and FT4 groups

	Geometric Mean of Thyroid Function Index During Observation Period, mIU/L				P-value
	TSH (≤2.0)		TSH (> 2.0)
	FT4(> 16)	FT4(≤16)	FT4(> 16)	FT4(≤16)
Cases/person-years	40/575	45/378	40/381	55/375
Model 1^a	1.00	1.706 (1.113, 2.615)	1.502 (0.969, 2.329)	2.066 (1.375, 3.106)	0.005
Model 2^b	1.00	1.755 (1.145, 2.691)	1.522 (0.982, 2.360)	2.154 (1.428, 3.251)	0.003
Model 3^c	1.00	1.874 (1.199, 2.928)	1.600 (1.010, 2.536)	2.131 (1.380,3.291)	0.006

^a Estimates are calculated in Cox proportional hazards models. Model 1, unadjusted
^b Model 2 was further adjusted for sex and age based on model 1
^c Model 3 was further adjusted for BMI, PBG, LDL and GHB based on model 2

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