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Table 3 Deterioration of glycemic control positively correlated with increased GDI

From: Glycemic deviation index: a novel method of integrating glycemic numerical value and variability

Items

Normal

(n = 4)

Mild

(n = 9)

Moderate

(n = 11)

Severe

(n = 6)

P-Value

HbA1c (%)

6.28 ± 0.76

8.58 ± 1.66

9.55 ± 1.85

10.40 ± 0.85

P<0.001#

GA (%)

15.14 ± 2.77

23.82 ± 6.11

27.75 ± 6.21

30.73 ± 5.87

P<0.01*

log-FBGa (mmol/L)

0.79 ± 0.10 (6.23 ± 1.30)

0.84 ± 0.06 (6.98 ± 0.88)

0.92 ± 0.08 (8.54 ± 1.71)

1.02 ± 0.11 (10.76 ± 2.64)

P<0.001*

MBG (mmol/L)

7.00 ± 0.27

7.88 ± 0.63

10.96 ± 1.13

13.55 ± 1.56

P<0.001*

sqrt-AUCH-Lb (mmol/L∙ day)

0.48 ± 0.32 (0.31 ± 0.21)

0.93 ± 0.20 (0.90 ± 0.39)

1.79 ± 0.23 (3.27 ± 0.79)

2.40 ± 0.29 (5.83 ± 1.53)

P<0.001*

SDBG (mmol/L)

1.06 ± 0.36

2.08 ± 0.50

2.77 ± 0.77

3.32 ± 1.01

P<0.001*

MAGE (mmol/L)

2.15 ± 0.55

3.98 ± 1.15

4.84 ± 1.49

5.27 ± 1.52

P<0.01*

MODD (mmol/L)

1.07 ± 0.47

2.07 ± 0.76

2.68 ± 0.55

3.41 ± 1.06

P<0.01#

Diabetes complications

18.75%

27.75%

33.98%

37.48%

 
  1. The results are expressed as mean ± SD. *, One-way ANOVA; #, Brown–Forsythe test. A P value of < 0.05 was considered to be statistically significant. alog-transformation; bsquare-root transformation. Original data are shown in parentheses
  2. HbA1c Glycosylated hemoglobin, GA Glycated Albumin, FBG Fasting blood glucose, MBG Mean blood glucose, AUC Area under the curve, SDBG Standard deviation of blood glucose, MAGE Mean amplitude of glycemic excursions, MODD Mean of daily differences