Manifestations of left ventricular dysfunction and arrhythmia in patients with chronic hypoparathyroidism and pseudohypoparathyroidism: a preliminary study

Table 2 Comparison of echocardiographic parameters across different subgroups

Variables	HP N = 18	Control A N = 18	PHP N = 8	Control B N = 8	P^a value	P^b value	P^c value	P^c,d	P^c,e	P^c,f
Age of evaluation (y)	45.4 ± 15.4	45.9 ± 14.8	20.6 ± 5.3	22.6 ± 6.4	0.501	0.120	0.000	–	–	–
BMI (kg/m²)	25.1 ± 3.9	23.0 ± 2.1	22.6 ± 3.3	18.6 ± 3.9	0.050	0.004	0.074	–	–	–
HR (beats/min)	73.6 ± 9.9	69.4 ± 10.6	70.0 ± 4.6	72.3 ± 5.6	0.269	0.417	0.404	–	–	–
					Adjusted for age at evaluation and BMI
IVSd (mm)	7.6 ± 1.1	7.8 ± 1.9	6.4 ± 0.6	7.1 ± 1.6	0.600	0.153	0.009	0.141	0.159	0.173
LVPWd (mm)	7.7 ± 1.0	7.8 ± 1.6	6.4 ± 0.6	6.5 ± 1.4	0.452	0.336	0.005	0.186	0.247	0.237
LVEDD (mm)	46.9 ± 5.1	46.6 ± 3.9	45.1 ± 5.0	42.9 ± 4.5	0.732	0.836	0.398	0.124	0.130	0.141
LVEF (%)	68.4 ± 6.4	70.8 ± 6.1	66.5 ± 7.4	70.4 ± 7.1	0.275	0.314	0.422	0.763	0.939	0.855
LVM (g)	117.9 ± 32.1	120.2 ± 43.9	86.2 ± 20.3	87.5 ± 26.6	0.517	0.288	0.020	0.783	0.888	0.818
LVMI (g/m²)	69.2 ± 16.0	71.4 ± 27.0	54.6 ± 6.4	51.3 ± 12.2	0.644	0.824	0.050	0.923	0.943	0.863
RWT	0.33 ± 0.04	0.34 ± 0.07	0.28 ± 0.04	0.31 ± 0.07	0.557	0.369	0.022	0.023	0.032	0.039
E/A ratio	0.9 ± 0.2	NA	1.4 ± 0.1	NA	–	–	0.000	0.043	0.024	0.036

Date represent the means (SD)
^a: comparison between HP and control A, adjusted for BMI
^b: comparison between PHP and control B, adjusted for BMI
^c: comparison between HP and PHP
^d: P value adjusted for gender, age at evaluation, and BMI
^e: P value adjusted for gender, age at evaluation, BMI and serum calcium
^f: P value adjusted for gender, age at evaluation, BMI, and serum phosphorus
Abbreviations: HP hypoparathyroidism; PHP pseudohypoparathyroidism; BMI body mass index; HR heart rate; IVSd interventricular septum end-diastolic thickness; LVPWd left ventricular posterior wall end-diastolic thickness; LVEDD left ventricular end-diastolic diameter; LVEF left ventricular ejection fraction; LVM left ventricular mass; LVMI left ventricular mass index; RWT relative wall thickness; E early diastolic mitral inflow velocity; A: late diastolic mitral inflow velocity

ISSN: 1472-6823