Skip to main content

Table 6 Influence of rs12998 and rs35431622 polymorphisms of KISS1 gene on Endocrine and Obesity linked parameters, in PCOS patients and controls

From: Influence of KISS1 gene polymorphisms on the risk of polycystic ovary syndrome and its associated variables, in Saudi women

Parameters

 

Genotypes of rs12998

P-value (Pair wise Comparison)

Genotypes of rs35431622

P-value (Pair wise Comparison)

GG

GA

AA

AA

AT

No. C

n = 88

n = 17

n = 4

n = 101

n = 8

No. P

n = 87

n = 12

n = 5

n = 97

n = 7

Obesity linked Parameters

 BMI (Kg\m2)

C

29.82 ± 7.04

30.45 ± 9.33

29.00 ± 4.02

GG/GA = 0.752

29.54 ± 7.18

34.27 ± 7.95

AA/AT = 0.987

GG/AA = 0.503

P

29.44 ± 5.86

28.88 ± 5.48

31.04 ± 9.96

GG/GA = 0.748

29.55 ± 6.05

28.11 ± 5.32

AA/AT = 0.987

GG/AA = 0.740

 Waist-hip ratio

C

0.77 ± 0.07

0.79 ± 0.07

0.79 ± 0.06

GG/GA = 0.218

0.77 ± 0.06

0.79 ± 0.09

AA/AT = 0.640

GG/AA = 0.420

P

0.84 ± 0.07

0.81 ± 0.07

0.89 ± 0.15

GG/GA = 0.254

0.84 ± 0.07

0.81 ± 0.06

AA/AT = 0.965

GG/AA = 0.317

Endocrine Parameters

 FSH (IU\L)

C

4.73 ± 1.54

5.04 ± 1.48

6.10 ± 1.83

GG/GA = 0.434

4.84 ± 1.50

4.61 ± 2.16

AA/AT = 0.070

GG/AA = 0.230

P

5.11 ± 1.53

4.59 ± 1.26

5.80 ± 2.18

GG/GA = 0.212

5.07 ± 1.53

5.20 ± 1.77

AA/AT = 0.972

GG/AA = 0.343

 LH (IU\L)

C

4.55 ± 1.42

4.43 ± 1.25

5.20 ± 1.53

GG/GA = 0.738

4.54 ± 1.35

4.81 ± 1.86

AA/AT = 0.163

GG/AA = 0.460

P

14.88 ± 8.03

11.36 ± 2.47

13.82 ± 2.67

GG/GA = 0.135

14.46 ± 7.69

13.95 ± 3.72

AA/AT = 0.466

GG/AA = 0.488

 LH-FSH ratio

C

0.99 ± 0.38

0.94 ± 0.38

0.87 ± 0.25

GG/GA = 0.526

0.97 ± 0.37

1.11 ± 0.34

AA/AT = 0.798

GG/AA = 0.534

P

2.97 ± 1.06

2.82 ± 1.29

2.55 ± 0.71

GG/GA = 0.650

2.94 ± 1.09

2.85 ± 0.88

AA/AT = 0.695

GG/AA = 0.263

 Kisspeptin (ng\ml)

C

0.39 ± 0.07

0.37 ± 0.05

0.40 ± 0.10

GG/GA = 0.150

0.39 ± 0.06

0.41 ± 0.07

AA/AT = 0.811

GG/AA = 0.946

P

0.42 ± 0.16

0.38 ± 0.14

0.31 ± 0.25

GG/GA = 0.399

0.41 ± 0.16

0.35 ± 0.11

AA/AT = 0.184

GG/AA = 0.156

  1. *Significant, C control, P PCOS patients, BMI Body mass index, LH luteinizing hormone, FSH follicle stimulating hormone, p values indicate comparison of features between wild-type homozygous and mutant allele carriers (mutant homozygous and heterozygous). For SNP rs35431622: TT = 0, in both PCOS patients and controls
Back to article page

BMC Endocrine Disorders

ISSN: 1472-6823

Contact us