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Table 5 Influence of rs372790354 polymorphism of KISS1 gene on Endocrine and Obesity linked parameters, in PCOS patients and controls

From: Influence of KISS1 gene polymorphisms on the risk of polycystic ovary syndrome and its associated variables, in Saudi women

Parameters

 

Genotypes of rs372790354

P-value (Pair wise Comparison)

GG

GA

AA

No. C

n = 92

n = 17

n = 0

No. P

n = 86

n = 13

n = 5

Obesity linked Parameters

 BMI (Kg\m2)

C

29.88 ± 7.21

29.89 ± 8.06

–

GG/GA = 0.776

–

P

29.43 ± 5.90

29.62 ± 5.01

29.40 ± 10.4

GG/GA = 0.902

GG/AA = 0.991

 Waist-hip ratio

C

0.77 ± 0.06

0.79 ± 0.07

–

GG/GA = 0.389

–

P

0.83 ± 0.07

0.84 ± 0.08

0.88 ± 0.16

GG/GA = 0.925

GG/AA< 0.05*

Endocrine Parameters

 FSH (IU\L)

C

4.76 ± 1.60

5.17 ± 1.22

–

GG/GA = 0.063

–

P

5.16 ± 1.53

4.41 ± 1.08

5.52 ± 2.39

GG/GA = 0.092

GG/AA = 0.624

 LH (IU\L)

C

4.53 ± 1.45

4.68 ± 1.02

–

GG/GA = 0.135

–

P

12.54 ± 2.55

11.85 ± 3.43

14.93 ± 8.02

GG/GA = 0.051

GG/AA< 0.05*

 LH-FSH ratio

C

0.99 ± 0.39

0.94 ± 0.26

–

GG/GA = 0.277

–

P

2.96 ± 1.08

2.91 ± 1.12

2.45 ± 0.62

GG/GA = 0.881

GG/AA = 0.144

 Kisspeptin (ng\ml)

C

0.42 ± 0.15

0.37 ± 0.06

–

GG/GA = 0.106

–

P

0.41 ± 0.16

0.42 ± 0.15

0.28 ± 0.19

GG/GA = 0.887

GG/AA< 0.05*

  1. *Significant, C control, P PCOS patients, BMI Body mass index, LH luteinizing hormone, FSH follicle stimulating hormone, p values indicate comparison of features between wild-type homozygous and mutant allele carriers (mutant homozygous and heterozygous)
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BMC Endocrine Disorders

ISSN: 1472-6823

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