Fig. 1

Position of aryl hydrocarbon receptor (AHR) variant. a. Schematic diagram of the AHR gene including the amino acid (aa) positions of all 11 exons (all coding). The location of the AHR variant in our patient (p.Thre583Met) is shown in exon 10, in addition to variants previously studied in the setting of acromegaly (p.Arg554Lys and p.Val570Ile). Functional domains based on extrapolations from mouse Ahr [4] are indicated. b. Threonine phosphorylation map of AHR by NetPhos 3.1 Server showing our patient’s variant located at a predicted phosphorylation site [3]. c. The alignment of protein sequences from different species showing our patient’s variant at aa position 583 to be more conserved compared to the previously studied variants at aa positions 554 and 570