From: Clinical characterization of patients with primary aldosteronism plus subclinical Cushing’s syndrome
Study diseases | P values in between-group comparisons | ||||||
---|---|---|---|---|---|---|---|
PA (n = 45) | SCS (n = 12) | PASCSa (n = 14) | Allb | PA vs. PASCSc | SCS vs. PASCSc | PA vs. SCSc | |
Clinical characteristics | |||||||
Age, y | 56.2 ± 1.0 | 62.5 ± 12.6 | 60.8 ± 13.1 | NS | |||
Sex, female, n (%) | 29 (64.4) | 7 (58.3) | 11 (78.6) | NS | |||
BMI, kg/m2 | 24.9 ± 4.2 | 25.2 ± 5.9 | 26.0 ± 4.4 | NS | |||
SBP, mmHg | 165.6 ± 26.1 | 145.6 ± 26.9 | 150.1 ± 27.2 | < 0.05 | NS | NS | NS |
DBP, mmHg | 96.0 ± 13.6 | 80.0 ± 12.7 | 90.5 ± 16.4 | < 0.01 | NS | NS | < 0.01 |
Comorbidities | |||||||
Hypertension, n (%) | 45 (100.0) | 9 (75.0) | 13 (92.9) | < 0.01 | NS | NS | < 0.05 |
Diabetes mellitus, n (%) | 6 (14.0) | 6 (50.0) | 7 (50.0) | < 0.01 | < 0.05 | NS | NS |
Dyslipidemia, n (%) | 25 (56.8) | 10 (83.3) | 9 (64.3) | NS | |||
Laboratory characteristics | |||||||
FPG, mg/dL | 103.8 ± 28.5 | 150.0 ± 60.7 | 131.6 ± 52.1 | < 0.005 | NS | NS | < 0.01 |
HbA1c NGSP, % | 5.7 ± 0.9 | 7.3 ± 2.2 | 6.5 ± 2.1 | < 0.01 | NS | NS | < 0.01 |
TC, mg/dL | 197.5 ± 42.5 | 208.1 ± 54.7 | 195.1 ± 30.4 | NS | |||
TG, mg/dL | 131.7 ± 88.2 | 148.3 ± 52.9 | 141.3 ± 70.3 | NS | |||
HDL-C, mg/dL | 55.2 ± 15.3 | 53.6 ± 13.9 | 57.0 ± 12.4 | NS | |||
LDL-C, mg/dL | 117.6 ± 40.3 | 127.2 ± 47.5 | 112.9 ± 23.6 | NS | |||
Serum potassium, mEq/L | 3.3 ± 0.7 | 4.0 ± 0.5 | 3.2 ± 0.8 | < 0.01 | NS | < 0.01 | < 0.01 |
Serum calcium, mg/dL | 9.4 ± 0.4 | 9.5 ± 0.4 | 9.6 ± 0.4 | NS | |||
Serum phosphorus, mg/dL | 3.5 ± 0.5 | 3.3 ± 0.9 | 3.3 ± 0.4 | NS | |||
UA, mg/dL | 5.1 ± 1.1 | 4.9 ± 1.1 | 5.3 ± 1.3 | NS | |||
Serum ALP, U/L | 212.3 ± 46.3 | 256.8 ± 70.0 | 279.1 ± 105.4 | < 0.005 | < 0.01 | NS | NS |
Erythrocyte, 106/μL | 4.4 ± 0.5 | 4.5 ± 0.7 | 4.5 ± 0.3 | NS | |||
Hemoglobin, g/dL | 13.2 ± 1.6 | 13.7 ± 2.0 | 13.2 ± 1.4 | NS | |||
Hematocrit, % | 39.0 ± 4.1 | 41.3 ± 5.5 | 39.2 ± 4.1 | NS | |||
Leukocyte, 103/μL | 5.8 ± 1.6 | 6.6 ± 1.3 | 5.7 ± 2.0 | NS | |||
Neutrophil, % | 61.7 ± 7.2 | 64.7 ± 12.7 | 63.7 ± 5.3 | NS | |||
Lymphocyte, % | 28.9 ± 6.8 | 27.2 ± 11.4 | 28.0 ± 6.2 | NS | |||
Eosinocyte, % | 3.9 ± 3.4 | 2.4 ± 2.1 | 2.4 ± 1.4 | NS | |||
Imaging characteristics | |||||||
Laterality of tumord | |||||||
Left-sided, n (%) | 28 (62.2) | 9 (75.0) | 7 (50.0) | ||||
Right-sided, n (%) | 14 (31.1) | 3 (25.0) | 5 (35.7) | ||||
Bilateral, n (%) | 3 (6.7) | 0 (0.0) | 2 (14.3) |