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Table 1 Clinical, laboratory, and imaging characteristics of untreated patients with PA, SCS, or PASCS

From: Clinical characterization of patients with primary aldosteronism plus subclinical Cushing’s syndrome

 Study diseasesP values in between-group comparisons
PA
(n = 45)
SCS
(n = 12)
PASCSa
(n = 14)
AllbPA vs. PASCScSCS vs. PASCScPA vs. SCSc
Clinical characteristics
 Age, y56.2 ± 1.062.5 ± 12.660.8 ± 13.1NS   
 Sex, female, n (%)29 (64.4)7 (58.3)11 (78.6)NS   
 BMI, kg/m224.9 ± 4.225.2 ± 5.926.0 ± 4.4NS   
 SBP, mmHg165.6 ± 26.1145.6 ± 26.9150.1 ± 27.2<  0.05NSNSNS
 DBP, mmHg96.0 ± 13.680.0 ± 12.790.5 ± 16.4<  0.01NSNS<  0.01
Comorbidities
 Hypertension, n (%)45 (100.0)9 (75.0)13 (92.9)<  0.01NSNS<  0.05
 Diabetes mellitus, n (%)6 (14.0)6 (50.0)7 (50.0)<  0.01<  0.05NSNS
 Dyslipidemia, n (%)25 (56.8)10 (83.3)9 (64.3)NS   
Laboratory characteristics
 FPG, mg/dL103.8 ± 28.5150.0 ± 60.7131.6 ± 52.1<  0.005NSNS<  0.01
 HbA1c NGSP, %5.7 ± 0.97.3 ± 2.26.5 ± 2.1<  0.01NSNS<  0.01
 TC, mg/dL197.5 ± 42.5208.1 ± 54.7195.1 ± 30.4NS   
 TG, mg/dL131.7 ± 88.2148.3 ± 52.9141.3 ± 70.3NS   
 HDL-C, mg/dL55.2 ± 15.353.6 ± 13.957.0 ± 12.4NS   
 LDL-C, mg/dL117.6 ± 40.3127.2 ± 47.5112.9 ± 23.6NS   
 Serum potassium, mEq/L3.3 ± 0.74.0 ± 0.53.2 ± 0.8<  0.01NS<  0.01<  0.01
 Serum calcium, mg/dL9.4 ± 0.49.5 ± 0.49.6 ± 0.4NS   
 Serum phosphorus, mg/dL3.5 ± 0.53.3 ± 0.93.3 ± 0.4NS   
 UA, mg/dL5.1 ± 1.14.9 ± 1.15.3 ± 1.3NS   
 Serum ALP, U/L212.3 ± 46.3256.8 ± 70.0279.1 ± 105.4<  0.005<  0.01NSNS
 Erythrocyte, 106/μL4.4 ± 0.54.5 ± 0.74.5 ± 0.3NS   
 Hemoglobin, g/dL13.2 ± 1.613.7 ± 2.013.2 ± 1.4NS   
 Hematocrit, %39.0 ± 4.141.3 ± 5.539.2 ± 4.1NS   
 Leukocyte, 103/μL5.8 ± 1.66.6 ± 1.35.7 ± 2.0NS   
 Neutrophil, %61.7 ± 7.264.7 ± 12.763.7 ± 5.3NS   
 Lymphocyte, %28.9 ± 6.827.2 ± 11.428.0 ± 6.2NS   
 Eosinocyte, %3.9 ± 3.42.4 ± 2.12.4 ± 1.4NS   
Imaging characteristics
 Laterality of tumord       
 Left-sided, n (%)28 (62.2)9 (75.0)7 (50.0)    
 Right-sided, n (%)14 (31.1)3 (25.0)5 (35.7)    
 Bilateral, n (%)3 (6.7)0 (0.0)2 (14.3)    
  1. Values are expressed as mean ± SD or count (%)
  2. PA primary aldosteronism, SCS subclinical Cushing’s syndrome, PASCS primary aldosteronism plus subclinical Cushing’s syndrome, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, HbA1c hemoglobin A1c, NGSP national glycohemoglobin standardization program, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, UA uric acid, ALP alkaline phosphatase, NS not significant, SD standard deviation
  3. aPatients with primary aldosteronism plus subclinical Cushing’s syndrome
  4. bAnalyzed according to the one-way analysis of variance
  5. cBonferroni’s correction was applied to the p values from Student’s t-test or Fisher’s exact test in multiple comparisons between two groups
  6. dDetermined by computed tomography, adrenal venous sampling, and 131I-adosterol adrenal scintigraphy
  7. A value of p <  0.05 was considered statistically significant