Steroid metabolites for diagnosing and predicting clinicopathological features in cortisol-producing adrenocortical carcinoma

Table 3 The correlation coefficient (R) and statistical significance (p-value) for steroids and clinicopathological parameters in ACC

	ENSAT		Weiss score		Ki-67 index		Tumor size		Overall survival
	R-value	P-value	R-value	P-value	R-value	P-value	R-value	P-value	R-value	P-value
Serum steroids
Progesterone	−0.11	0.82	−0.12	0.82	0.09	0.86	−0.41	0.42	0.21	0.66
17-hydroxyprogesterone	0.40	0.37	0.49	0.33	0.58	0.23	−0.46	0.36	− 0.57	0.19
11-deoxycortisol	0.80	0.03	− 0.71	0.12	0.17	0.75	0.38	0.46	0.28	0.54
Cortisol	−0.14	0.79	0.53	0.27	−0.48	0.28	0.19	0.71	0.57	0.32
11-deoxycorticosterone	0.54	0.21	−0.79	0.06	0.02	0.97	0.62	0.19	0.42	0.34
Corticosterone	−0.01	0.98	−0.70	0.12	0.00	1.00	0.31	0.55	−0.06	0.90
Aldosterone	0.55	0.20	−0.11	0.84	0.79	0.06	−0.18	0.73	−0.30	0.51
Pregnenolone	−0.03	0.96	0.08	0.89	0.60	0.21	0.25	0.64	0.04	0.94
17-hydroxypregnenolone	−0.01	0.99	0.77	0.07	0.33	0.53	−0.41	0.42	−0.29	0.53
Androstenedione	0.33	0.52	0.12	0.85	0.03	0.96	0.66	0.23	0.20	0.70
Testosterone	0.28	0.54	0.44	0.38	0.86	0.03	−0.21	0.69	−0.65	0.11
DHEAS	−0.10	0.83	0.58	0.23	0.07	0.89	0.16	0.77	0.29	0.52
Urinary steroids
11-hydroandrosterone	0.33	0.47	0.52	0.29	−0.19	0.72	0.16	0.76	−0.05	0.92
11-hydroxyetiocholanolone	−0.15	0.75	0.60	0.21	−0.56	0.25	0.26	0.62	0.12	0.79
11-ketoandrosterone	0.33	0.46	0.13	0.80	−0.46	0.36	0.09	0.86	−0.03	0.94
11-ketoetiocholanolone	−0.01	0.98	0.42	0.41	−0.68	0.14	0.13	0.80	0.26	0.57
Androsterone	0.49	0.26	0.45	0.37	0.56	0.24	0.12	0.82	−0.15	0.75
Etiocholanolone	0.15	0.74	0.60	0.21	−0.02	0.98	0.19	0.71	0.15	0.75
Dehydroepiandrosterone	0.14	0.76	0.60	0.21	0.35	0.50	0.21	0.69	0.02	0.96

DHEA-S dehydroepiandrosterone sulfate, R-values with P < 0.05 printed in boldface

ISSN: 1472-6823