Steroid metabolites for diagnosing and predicting clinicopathological features in cortisol-producing adrenocortical carcinoma

Table 2 Receiver operating characteristics (ROC) for steroid metabolites with sensitivity for detecting ACC > 85%

	AUC	Cuff-off value	Unit	Sensitivity (%)	Specificity (%)	Accuracy
Serum steroids
17-hydroxyprogesterone	0.898	0.62	ng/mL	100	52	0.633
11-deoxycortisol	0.789	1.14	ng/mL	86	52	0.594
Cortisol	0.602	9.75	μg/dL	100	17	0.367
11-deoxycorticosterone	0.909	0.40	ng/mL	86	96	0.938
Corticosterone	0.800	1.82	ng/mL	100	28	0.438
Aldosterone	0.494	24.04	pg/mL	100	8	0.290
Pregnenolone	0.898	0.133	ng/mL	100	65	0.733
17-hydroxypregnenolone	0.954	1.78	ng/mL	100	88	0.906
Androstenedione	0.928	1.52	ng/mL	100	64	0.710
DHEAS	0.851	32.50	μg/dL	100	71	0.774
Urinary steroids
11-hydroxyetiocholanolone	0.489	0.37	mg/day	86	53	0.615
11-ketoetiocholanolone	0.514	0.29	mg/day	86	58	0.654

ACC adrenocortical carcinomas, DHEA-S dehydroepiandrosterone sulfate, AUC area under the curve

ISSN: 1472-6823