Fig. 3

Effects of MAPK14 knockout on the development of prolactinoma in DRD2^−/− mice. a Plasma PRL levels in WT mice, DRD2^−/− mice and DRD2^−/−MAPK14^+/− mice. ^**P < 0.01 vs. WT mice; ^#P < 0.05 vs. DRD2^−/− mice, (n = 3). b Relative PRL mRNA expression levels in the pituitary gland of mice. ^***P < 0.001 vs. WT mice; ^##P < 0.01 vs. DRD2^−/− mice, (n = 3). c Pituitary gland weight/body weight ratio. ^***P < 0.001 vs. WT mice; ^###P < 0.001 vs. DRD2^−/− mice, (n = 6). d PRL protein expression levels in the pituitary gland of mice. e Relative PRL protein expression levels were quantified and normalized to β-actin. ^**P < 0.01 vs. WT mice, ^#P < 0.05 vs. DRD2^−/− mice, (n = 3)