Fig. 2

Effects of MAPK14 knockout on the development of prolactinoma in ES-induced mice. a Plasma PRL levels in the WT mice, ES-injected mice and ES-injected MAPK14^−/− mice. ^**P < 0.01 vs. WT; ^##P < 0.01 vs. E2, (n = 3). b Relative PRL mRNA expression levels in the pituitary gland of mice. ^**P < 0.01 vs. WT; ^##P < 0.01 vs. ES, (n = 3). c Pituitary gland weight/body weight ratio. ^***P < 0.001 vs. WT; ^###P < 0.001 vs. ES, (n = 6). d PRL protein expression levels in the pituitary gland of mice. e Relative PRL protein expression levels were quantified and normalized to β-actin. ^**P < 0.01 vs. WT; ^#P < 0.05 vs. ES, (n = 3)