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Table 1 Comparison of hormonal, antropometric, clinical, radiologic, biochemical and metabolic parameters between NFAI and ACS

From: The prevalence and characteristics of non-functioning and autonomous cortisol secreting adrenal incidentaloma after patients’ stratification by body mass index and age

Variables NFAI (N = 290) ACS (N = 142) P
Age (yr) 61.76 ± 11.13 [62.67 (53.34–70.47)] 64.90 ± 12.08 [66.1 (54.94–74.8)] 0.008
Maximal tumor size (mm) 23.7 ± 11.1 [22.2 (16–29.0)] 30.3 ± 13.3 [30 (22.5–35.5)] < 0.001
Size of rightsided tumor (mm) 23.7 ± 9.8 [23 (17.3–28)] 28.3 ± 11.1 [28.5 (20.0–35.0)] < 0.001
Size of leftsided tumor (mm) 21.5 ± 11.9 [20 (14–25)] 28.4 ± 15.5 [26 (20–35)] < 0.001
Basal serum cortisol (nmol/l) 398.33 ± 128.24 [384 (320–451.8)] 481.02 ± 240.00 [457 (350.25–556.25)] < 0.001
Serum cortisol after ODST (nmol/l)a 32.8 ± 6.7 [29.4 (27.6–37.6)] 108.6 ± 277.4 [67.8 (55.9–87.4)] < 0.001
ACTH (pmol/l) 2.22 ± 1.42 [1.90 (1.17–2.81)] 3.34 ± 7.54 [1.58 (1.11–2.58)] 0.398
Basal DHEAS (μmol/L) 1.92 ± 1.29 [1.7 (1–2.43)] 1.09 ± 0.94 [0.9 (0.4–1.4)] < 0.001
DHEAS after ODST (μmol/L) 0.93 ± 0.76 [0.7 (0.4–1.2)] 0.74 ± 0.67 [0.5 (0.3–1)] 0.027
Aldosteron (nmol/l) 0.20 ± 0.13 [0.17 (0.11–0.25)] 0.26 ± 0.21 [0.21 (0.12–0.3)] 0.039
Plasma Renin Activity – PRA (μg/l/h) 1.25 ± 2.29 [0.38 (0.16–1.37)] 1.68 ± 3.19 [0.59 (0.19–1.63)] 0.132
TSH (mE/l) 2.93 ± 2.50 [1.68 (1.13–5.43)] 2.75 ± 2.57 [1.41 (0.6–5.73)] 0.186
Body mass (kg) 80.51 ± 15.92 [79.6 (68.75–89.45)] 77.15 ± 16.37 [74.8 (65.78–87.18)] 0.023
BMI (kg/m2) 29.33 ± 5.62 [28.59 (25.61–32.13)] 28.56 ± 5.37 [27.77 (25.48–31.28)] 0.287
Systolic blood
pressure (mm Hg)
138.36 ± 18.94 [140 (124–151)] 141.63 ± 24.02 [140 (125–155)] 0.339
Diastolic blood
pressure (mm Hg)
77.74 ± 11.51 [76 (70–85)] 77.72 ± 12.02 [75 (70–85)] 0.896
Fasting glucose (mmol/liter) 5.75 ± 1.40 [5.4 (4.9–6.13)] 5.78 ± 1.71 [5.4 (5–6.1)] 0.876
Total cholesterol (mmol/liter) 5.14 ± 1.14 [5.1 (4.4–5.8)] 5.09 ± 1.17 [5.1 (4.3–5.75)] 0.716
HDL (mmol/liter) 1.31 ± 0.36 [1.3 (1.1–1.5)] 1.32 ± 0.41 [1.2 (1–1.5)] 0.849
LDL (mmol/liter) 3.15 ± 0.98 [3.1 (2.4–3.78)] 3.05 ± 1.00 [3 (2.5–3.7)] 0.473
Triglycerides (mmol/liter) 1.75 ± 0.95 [1.5 (1.2–2.1)] 1.77 ± 0.88 [1.6 (1.2–2.1)] 0.622
  1. afor 70 patients, data were provided as below 27.6, for 20 below 28 and for 1 below 31.3
  2. Data are given as mean ± SD [Median (25–75%)]