Fig. 3
From: A clinical trial to evaluate the effect of statin use on lowering aldosterone levels
Beneficial pleiotropic effects of statin medications. Data from the past decade have shown that in addition to their classic LDL-cholesterol lowering effects, statins also function to improve cardiovascular health by mitigating oxidative stress, improving endothelial dysfunction through increased NO function, and decreasing high-sensitivity C-Reactive Protein levels. We propose that statins’ aldosterone-lowering effect represents another mechanism by which statins reduce cardiovascular risk apart from their influence on LDL-cholesterol