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Table 3 Best cut-off points for detection of MS in patients with T1D

From: Comparison of indirect markers of insulin resistance in adult patients with Double Diabetes

Index

AUC (IC95%)

Cut-off value

Sensitivity

Specificity

LR+

LR-

eGDR, mg/kg/min

0.93 (0.87–0.98)

< 7.32

85%

84%

5.31

0.17

WHtR

0.70 (0.68–0.89)

> 0.52

77%

70%

2.58

0.33

eIS

0.68 (0.56–0.81)

< 2.92

70%

54%

1.52

0.55

Female

0.72 (0.57–0.86)

< 3.10

69%

66%

2.02

0.46

Male

0.63 (0.40–0.87)

< 2.92

72%

63%

1.94

0.44

lnGDR, mg/kg/min

0.77 (0.65–0.88)

< 1.8

82%

73%

3.03

0.24

Female

0.77 (0.64–0.91)

< 1.81

80%

69%

2.58

0.28

Male

0.80 (0.64–0.97)

< 1.77

88%

80%

4.4

0.15

TG/HDL-c

0.83 (0.76–0.91)

> 2.0

86%

64%

2.39

0.21

Female

0.86 (0.77–0.95)

> 2.2

81%

78%

3.68

0.24

Male

0.78 (0.63–0.93)

> 2.5

82%

62%

2.15

0.29

VAI

0.86 (0.78–0.94)

> 1.84

82%

71%

2.84

0.25

  1. eGDR estimated glucose disposal rate, WHtR waist-to-height ratio, eIS estimated insulin sensitivity, lnGDR natural logarithm of glucose disposal rate, TG/HDL-c ratio triglycerides/HDL cholesterol, VAI visceral adiposity index