Subclinical hypothyroidism and the risk of cancer incidence and cancer mortality: a systematic review

BMC Endocrine Disorders

Table 3 Quality assessment of cohort studies using the Cochrane Tool to assess the risk of bias

Author, year	Selection of exposed and non-exposed from same population?	Can we be confident in the assessment of exposure?	Outcome of interest was not present at start of the study?	The study matched exposed and non-exposed for all the variables associated with the outcome of interest or did the statistical analysis adjust for these prognostic variables?	Can we be confident in the assessment of absence and presence of prognostic factors?	Can we be confident in the assessment of outcome?	Was the follow-up of cohorts adequate?	Were con-interventions similar between groups?
Kuijpens, 2005 [8]	DY	DY	DY	DY	DY	DY	PN	DY
Hellevik, 2009 [15]	DY	DY	DY	PY	DY	DY	PY	PY
Razvi, 2012 [16]	PY	DY	DY	PN	DY	DY	DY	PY
Waring, 2012 [64]	DY	DY	DY	PY	PY	DY	DY	PY
Tseng, 2015 [63]	PY	DY	DY	PY	DY	DY	DY	PY
Fighera, 2015 [61]	DN	DY	PN	PN/PY	DY	DY	PY	PY
Pinter, 2017 [62]	DY	DY	DY	PN	DY	DY	PY	PY

Abbreviations: DY definitely yes, low risk of bias, PY probably yes, PN probably no, DN definitely no, high risk of bias

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