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Table 2 Results of meta-analysisi and Meta-regression

From: Effect of lifestyle modifications on anthropometric, clinical, and biochemical parameters in adolescent girls with polycystic ovary syndrome: a systematic review and meta-analysis

Outcomes

N

aI2%

cPublication bias

Pooled SMD (95%CI)

bMeta-regression coefficient

(P-Value)

SMD

LCI

UCI

BMI

Intervention: lifestyle

4

69.9

0.088

−0.442

− 0.986

0.102

− 0.47 (0.119)

Intervention: Exercise

2

0.0

0.125

0.017

−0.226

0.260

−0.038 (0.896)

Intervention: Diet

4

0.0

0.147

−0.450

−0.760

− 0.139

− 0.47 (0.128)

Control

3

0.0

0.568

0.057

−0.242

0.356

Reference

FG score

1

      

Intervention: lifestyle

 

–

–

−0.509

−1.360

0.341

−0.57 (0.344)

Intervention: Exercise

1

–

–

−0.575

− 0.996

−0.153

− 0.63 (0.139)

Intervention: Diet

1

–

–

− 0.807

− 1.334

−0.280

− 0.86 (0.108)

Control

3

–

–

0.056

− 0.243

0.355

Reference

SBP

Intervention: lifestyle

2

72.2

0.602

− 0.070

−0.743

0.602

− 0.335 (0.651)

Intervention: Exercise

0

–

–

–

–

–

–

Intervention: Diet

1

0

–

0.267

− 0.372

0.907

0 .014 (0.986)

Control

1

–

–

0.252

− 0.588

1.091

Reference

DBP

Intervention: lifestyle

2

68.8

0.117

−0.216

− 0.855

0.422

0.135 (0.861)

Intervention: Exercise

0

–

–

–

–

–

–

Intervention: Diet

1

0

0.317

−0.451

− 1.093

0.191

−0.081 (0.905)

Control

1

–

–

− 0.349

− 1.192

0.494

Reference

Menstrual cycle

Intervention: lifestyle

0

–

–

–

–

–

NA

Intervention: Exercise

1

–

–

1.165

0.718

1.613

NA

Intervention: Diet

1

–

–

0.467

− 0.046

0.980

NA

Control

2

53

0.317

0.344

− 0.138

0.826

NA

FBS

Intervention: lifestyle

2

0

–

0.113

−0.219

0.445

0.246 (0.746)

Intervention: Exercise

1

94

0.317

−0.530

− 1.808

0.748

− 0.374 (0.636)

Intervention: Diet

1

–

–

− 0.092

− 0.729

0.545

0.052 (0.950)

Control

1

–

–

− 0.148

− 0.985

0.689

Reference

FBI

Intervention: lifestyle

2

78.3

0.117

−0.066

−0.824

0.693

−0.192 (0.814)

Intervention: Exercise

1

85.1

0.317

−0.126

−0.914

0.661

− 0.444 (0.779)

Intervention: Diet

1

0

–

− 0.108

−0.749

0.533

−0.234 (0.758)

Control

1

–

–

0.126

− 0.711

0.962

Reference

HOMA-IR

Intervention: lifestyle

2

0

0.254

0.000

− 0.312

0.312

–

Intervention: Exercise

1

0

0.317

0.000

−0.301

0.301

–

Intervention: Diet

0

–

–

–

–

–

–

Control

0

–

–

–

–

–

–

TG

Intervention: lifestyle

2

64.1

0.317

−0.097

− 0.705

0.511

− 0.095 (0.235)

Intervention: Exercise

1

0

0.317

−0.321

− 0.624

−0.018

− 0.180 (0.584)

Intervention: Diet

1

0

0.117

−0.097

−0.705

0.511

−0.041 (0.784)

Control

1

–

–

−0.236

−1.075

0.603

Reference

SHBG

Intervention: lifestyle

3

70.1

0.421

0.593

−0.004

1.191

0.341 (0.623)

Intervention: Exercise

0

–

–

–

–

–

–

Intervention: Diet

1

0

0.117

0.007

− 0.630

0.644

− 0.224 (0.784)

Control

1

–

–

0.235

− 0.604

1.074

Reference

HDL

Intervention: lifestyle

2

35.5

0.217

0.317

− 0.115

0.749

−0.075 (0.879)

Intervention: Exercise

1

0

0.117

0.089

−0.212

0.389

−0.311 (0.532)

Intervention: Diet

1

0

0.117

0.056

−0.582

0.694

−0.343 (0.560)

Control

1

–

–

0.400

− 0.445

1.245

Reference

LDL

Intervention: lifestyle

2

0

0.317

−0.059

− 0.390

0.273

0.063 (0.898)

Intervention: Exercise

1

54.1%

0.117

−0.431

− 0.882

0.021

−0.301 (0.542)

Intervention: Diet

1

0

0.117

−0.455

− 1.100

0.190

−0.333 (0.571)

Control

1

–

–

−0.122

− 0.958

0.715

Reference

FSH

Intervention: lifestyle

2

28.2

0.254

0.049

−0.337

0.435

0.202 (0.635)

Intervention: Exercise

0

0

–

− 0.207

−0.621

0.207

−0.063 (0.900)

Intervention: Diet

0

–

–

–

–

–

–

Control

1

–

–

− 0.144

−0.558

0.270

Reference

LH

Intervention: lifestyle

2

28.2

0.254

−1.235

−2.440

− 0.030

−2.115 (0.564)

Intervention: Exercise

0

0

–

− 0.561

−0.982

− 0.140

−0.982 (0.894)

Intervention: Diet

0

–

–

–

–

–

–

Control

1

–

–

0.420

0.003

0.838

Reference

TT

Intervention: lifestyle

1

–

–

0.140

−0.697

0.977

−0.0476 (0.952)

Intervention: Exercise

1

–

–

−0.288

− 0.703

0.128

− 0.476 (0.236)

Intervention: Diet

1

0

0.117

−0.050

− 0.686

0.586

−0.238 (0.592)

Control

1

0

0.117

0.188

−0.183

0.559

Reference

 FT

2

80.2

     

Intervention: lifestyle

  

0.542

−0.486

− 1.277

0.306

–

Intervention: Exercise

0

–

–

–

–

–

–

Intervention: Diet

1

81

0.117

−1.042

− 2.737

0.653

–

Control

0

–

–

–

–

–

Reference

BT

Intervention: lifestyle

0

–

–

–

–

–

–

Intervention: Exercise

0

–

–

–

–

–

–

Intervention: Diet

1

0

–

−0.073

−0.710

0.564

–

Control

0

–

–

–

–

–

Reference

AFI

Intervention: lifestyle

3

73.8

0.452

−0.778

− 1.425

−0.131

− 0.918 (0.400)

Intervention: Exercise

0

–

–

–

–

–

–

Intervention: Diet

0

–

–

–

–

–

–

Control

1

0

–

0.119

−0.718

0.955

Reference

AMH

Intervention: lifestyle

1

87.2

0.117

−1.230

−3.259

0.798

−1.084 (0.654)

Intervention: Exercise

1

–

–

−0.809

− 1.239

−0.378

−0.622 (0.541)

Intervention: Diet

0

–

–

–

–

–

–

Control

1

–

–

− 0.187

−0.601

0.227

Reference

  1. aHeterogeneity Index: Value upper 50% needs Random effect method of estimation
  2. bMeta-regression coefficient showed difference of intervention vs. control
  3. cEgger test of publication bias which test small-study effects
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BMC Endocrine Disorders

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