Association of circulating CEACAM1 levels and insulin sensitivity in gestational diabetes mellitus

BMC Endocrine Disorders

Table 1 Clinical characteristics and circulating CEACAM1 levels of the groups studied

Variable	GDM (n = 70)	NGT (n = 70)	P value
Age, years	28.54 ± 4.28	26.87 ± 3.79	0.016
Gestational age, weeks	24.66 ± 1.10	24.81 ± 1.12	0.404
Parity, times	1 (1–6)	2 (1–4)	0.058
BMI-1, kg/m2	21.54 ± 3.13	21.30 ± 3.00	0.605
BMI-2, kg/m2	24.35 ± 3.07	24.03 ± 3.21	0.673
Abdominal perimeter, cm	91.73 ± 6.17	90.20 ± 7.44	0.207
SBP, mm/Hg	113.40 ± 8.59	110.53 ± 8.54	0.061
DBP, mm/Hg	72.07 ± 6.32	70.79 ± 4.98	0.214
HbA1c, %	5.12 ± 0.76	4.96 ± 0.37	0.128
FPG, mmol/l	4.81 ± 0.68	4.36 ± 0.30	< 0.001
1hPG, mmol/l	9.60 ± 1.57	6.94 ± 1.34	< 0.001
2hPG, mmol/l	8.64 ± 1.55	6.26 ± 0.89	< 0.001
FINS, mU/l	4.88 (3.44–6.93)	3.22 (2.33–4.89)	0.002
1hPINS,mU/l	35.82 (20.83–46.77)	21.67 (14.36–31.90)	0.002
2hPINS,mU/l	32.30 (20.81–57.91)	23.30 (13.09–32.47)	< 0.001
HOMA-IR	1.03 (0.66–1.57)	0.65 (0.45–0.99)	0.004
HOMA-β	81.79 (60.05–118.38)	86.91 (54.10–131.61)	0.524
ISOGTT	151.00 (106.78–219.80)	278.89 (190.63–374.30)	< 0.001
AUCG, mmol/l	16.326 ± 2.254	12.251 ± 1.622	< 0.001
AUCI, mU/l	55.072 (39.09–75.00)	33.733 (23.51–54.53)	< 0.001
ΔI60/ΔG60	6.00 (3.75–8.01)	9.21 (4.89–14.56)	0.001
Neonatal weight, g	3477.78 ± 356.43	3333.13 ± 340.42	0.032
Family history of DM, %	10%	1.43%	< 0.001
CEACAM1, pg/ml	1889.82 ± 616.14	1758.92 ± 433.15	0.148

Note: Data are means ± standard deviation (SD) or medians (inter-quartile range)
Abbreviations: BMI-1 body mass index before pregnancy, BMI-2 body mass index in pregnancy, DBP diastolic blood pressure, SBP systolic blood pressure, FPG fasting plasma glucose, 1hPG 1-hour post-meal plasma glucose, 2hPG 2-h post-meal plasma glucose, FINS fasting insulin level, 1hPINS 1-h post-meal plasma insulin level, 2hPINS 2-h post-meal plasma insulin level, AUCG area under curve of glucose, AUCI area under curve of insulin

ISSN: 1472-6823