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Table 2 Genetic distribution of non-coding variants in patients and controls along with genetic models

From: Putative functional non-coding polymorphisms in SELP significantly modulate sP-selectin levels, arterial stiffness and type 2 diabetes mellitus susceptibility

Variants

Patients

N (%)

Controls

N (%)

Crude

Adjusted

Dominant Model

OR (95% CI)

p value

Co-dominant Model

OR (95% CI)

p value

Recessive Model

O R (95% CI)

p value

OR (95% CI)

p value

OR

p value

rs3917655 Genotypes

CC

132 (52.8)

149 (56.44)

reference

   

1.16

(0.82 to1.64)

0.407

1.19

(0.89 to 1.59)

0.235

1.68

(0.77 to 3.66)

0.187

CG

101 (40.4)

104 (39.39)

1.10 (0.76 to 1.57)

0.620

0.95

0.827

GG

17 (6.8)

11 (4.17)

1.74 (0.79 to 3.86)

0.170

1.70

0.259

Alleles

C

365 (73)

402 (76.14)

reference

    

G

135 (27)

126 (23.86)

1.18 (0.89 to 1.56)

0.250

  

rs3917657 Genotypes

CC

189 (75.6)

227 (85.98)

reference

   

1.98

(1.26 to 3.11)

0.003**

1.88

(1.24 to 2.85)

0.002**

2.67

(0.51 to 13.91)

0.218

CT

56 (22.4)

35 (13.25)

1.92 (1.20 to 3.05)

0.005**

1.94

0.014*

TT

5 (2)

2 (0.7)

3.00 (0.58 to 15.65)

0.191

3.16

0.214

Alleles

C

434 (86.8)

489 (92.61)

reference

    

T

66 (26.4)

39 (14.77)

1.91(1.26 to 2.89)

0.002**

   

rs3917739 Genotypes

GG

31 (12.4)

39 (14.77)

reference

   

1.22

(0.74 to 2.03)

0.433

1.21

(0.94 to 1.56)

0.311

1.31

(0.92 to 1.87)

0.135

GA

111(44.4)

128 (48.48)

1.09 (0.64 to 1.86)

0.750

1.24

0.483

AA

108 (43.2)

97 (36.74)

1.4 (0.81 to 2.41)

0.230

1.51

0.188

Alleles

G

173 (34.6)

206 (39.01)

reference

      

A

327 (65.4)

322 (60.98)

1.21 (0.94 to 1.56)

0.140

     

rs3917843 Genotypes

GG

183 (73.2)

186 (70.45)

reference

   

0.87

(0.59 to 1.28)

0.489

0.89

(0.63 to 1.25)

0.497

0.88

(0.26 to 2.91)

0.831

GA

62 (24.8)

72 (27.27)

0.87 (0.59 to 1.3)

0.511

1.24

0.483

AA

5 (2)

6 (2.27)

0.85 (0.25 to 2.82)

0.792

1.51

0.188

Alleles

G

428 (81.06)

444 (84.09)

reference

      

A

72 (13.64)

84 (15.90)

0.89 (0.63 to 1.25)

0.500

     

rs2235302 Genotypes

GG

98 (39.2)

86 (32.57)

reference

   

0.75

(0.52 to 1.08)

0.125

0.75

(0.57 to 0.98)

0.034*

0.58

(0.34 to 1.01)

0.049*

GA

129 (51.6)

138 (52.27)

0.82 (0.56 to 1.19)

0.300

0.79

0.284

AA

23 (9.2)

39 (14.77)

0.50 (0.28 to 0.91)

0.023*

0.54

0.046*

   

Alleles

G

325 (65)

310 (58.71)

reference

      

A

175 (35)

218 (41.29)

0.76 (0.59 to 0.98)

0.038*

     

rs3917779 Genotypes

CC

240 (96)

249 (94.32)

reference

   

–

–

–

CT

10 (4)

15 (5.68)

0.69 (0.30 to 1.57)

0.380

0.492

0.134

   

TT

–

–

–

      

Alleles

C

490 (98)

513 (97.16)

reference

      

T

10 (2)

15 (2.84)

0.70 (0.31 to 1.57)

0.384

     

rs3917854 Genotypes

GG

50 (42.73)

66 (56.89)

reference

   

1.77

(1.05 to 0.97)

0.030*

1.64

(1.12 to 2.41)

0.009**

2.45

(1.07 to 5.64)

0.027*

GA

47 (40.17)

41 (36.20)

1.51 (0.86 to 2.64)

0.140

1.32

0.386

AA

20 (17.09)

9 (7.75)

2.93 (1.23 to 6.98)

0.015*

2.96

0.030*

   

Alleles

G

147 (62.82)

173 (74.56)

reference

      

A

87 (37.17)

59 (25.43)

1.73 (1.16 to 2.58)

0.006**

     
  1. OR represents odds ratio, CI represents confidence interval; * represents p value significant at 0.05 level; ** represents p value significant at 0.01 level
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