Table 1 Demographic, clinic-pathological features, treatment, histological diagnosis, follow-up, IHC
Author | Gender | Age | Size, mm | Preoperative calcitonin serum level | Calcitonin-HIC | Calcitonin-IHC | CGRP-IHC | CgA-IHC | Syn-IHC | TG-IHC | CEA-IHC | RET mutation | Follow-up | Relapse |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sobol | F | 82 | 20 | Normal range | Negative | – | – | + | NA | NA | + | NA | 6 month | Lymph nodes, liver and bone |
Schmid 1 | M | 28 | NA | NA | Weak | NA | + | + | NA | – | – | NA | NA | NA |
Schmid 2 | M | 46 | NA | NA | Weak | NA | + | + | NA | – | – | NA | 19 month | Lymph nodes |
Schmid 3 | F | 45 | NA | NA | Weak | NA | – | + | NA | – | – | NA | NA | NA |
Schmid 4 | M | 37 | NA | NA | Negative | NA | – | + | NA | NA | – | NA | NA | NA |
Redding | F | 31 | 45 | 28 | Diffuse | + | NA | NA | + | NA | + | – | 43 month | Negative |
Bockhorn | F | 50 | 20 | 0,8 | Weak | NA | NA | + | NA | – | + | + | NA | NA |
Sand | F | 73 | NA | 5,3 | Weak | NA | NA | NA | NA | NA | NA | NA | Deceased 6 weeks | NA |
Dora | M | 43 | 20 | 4 | Diffuse | + | + | + | – | NA | – | NA | NA | |
Wang | M | 68 | 70 | 38 | Weak | + | NA | + | NA | – | + | NA | 12 months | Negative |
Giovanella | F | 43 | 48 | 4,7 | Diffuse | + | NA | NA | NA | NA | NA | NA | 24 months | NA |
Alapat | F | 16 | 30 | 4 | Diffuse | + | NA | + | NA | – | + | NA | 20 months | Negative |
Chernyavsky | F | 40 | 20 | 2,1 | Negative | – | NA | + | + | + | NA | + | 12 months | Negative |
Nakazawa | M | 76 | 60 | 22 | Weak | NA | NA | + | + | – | NA | NA | 18 months | Negative |
Frank-Raue 1 | F | 61 | 10 | 2,9 | Weak | + | NA | + | + | – | + | – | 72 months | Negative |
Frank-Raue 2 | M | 70 | 80 | < 2 | Weak | + | NA | + | + | – | + | – | 25 months | Pulmonary |
Frank-Raue 3 | F | 50 | 20 | 0,8 | Weak | + | NA | + | + | – | + | + | 150 months | Lymph modes |
Frank-Raue 4 | M | 47 | 30 | 2,6 | Focal | + | NA | + | + | – | + | – | 18 months | Local tumor infiltration |
Frank-Raue 5 | F | 53 | 45 | NA | Diffuse | + | NA | + | + | – | + | + | 21 months | Lymph node, bone, brain |
Frank-Raue 6 | M | 45 | 18 | 11 | Weak | + | NA | + | + | – | + | + | 21 months | Pulmonary |
Frank-Raue 7 | F | 45 | 55 | 1,5 | Focal | + | NA | + | + | – | + | + | 36 months | Pulmonary failure |
Ismi | NA | 57 | NA | 5,6 | Negative | – | NA | + | + | – | NA | NA | NA | NA |
Brutsaert | F | 49 | 26 | < 2 | Diffuse | NA | NA | NA | NA | NA | NA | + | NA | NA |
Kim | M | 34 | 10 | 3,7 | Negative | – | NA | + | + | + | – | – | 12 months | Negative |
Kasajima | F | 48 | 30 | 29 | Negative | NA | + | + | + | NA | NA | – | NA | NA |
Samà 1 | M | 60 | 38 | 7,8 | Focal | + | NA | + | NA | NA | + | – | 120 months | Negative |
Samà 2 | F | 66 | NA | 5 | NA | NA | NA | NA | NA | NA | NA | NA | 120 months | Negative |
Samà 3 | M | 53 | 12 | < 10 | Negative | – | NA | – | NA | NA | – | + | 36 months | Negative |
Samà 4 | M | 62 | 45 | 13 | Focal | + | NA | + | NA | NA | – | – | 36 months | Negative |
Parmer | F | 74 | 20 | Normal range | Negative | – | NA | + | + | – | + | NA | NA | NA |
Zhou | 11 M 8 F | ≥30 ys 3 cases < 30 ys 16 cases | ≤10mmm 14 cases > 10 mm 5 cases | NA | Positive: 8 cases Negative: 11 cases | + 8 cases - 11 cases | NA | + 18 cases - 1 case | + 19 cases | + 5 cases - 14 cases | + 4 cases - 15 cases | NA in 15 cases - In 4 cases | NA | NA |
Liu | F | 62 | 60 | 2 | Weak | + | NA | NA | NA | NA | NA | NA | NA | NA |
Gambardella | M | 59 | 10 | 5,21 | Weak | + | NA | + | NA | – | NA | – | 20 months | Laterocervical Lymh-node |