Table 3 Association of clinical and ultrasound (US) features with final histopathological result of 140 nodules with indeterminate diagnosis

Clinical and US features

Benign (n = 74)

Malignant (n = 66)

P* value

OR (CI 95%)

 Mean

49,6 ± 14,0 (18–84)

48,6 ± 13,3 (25–77)

0.663

0.99 (0.97–1.02)

 Female

64 (54.2%)

54 (45.8%)

 Male

9 (42.9%)

12 (57.1%)

0.339

1.58 (0.61–4.07)

 Size (cm)

2.0 (0.72–8.33)

1.43 (0.54–7.57)

0.049

0.58 (0.33–0.99)

 Solid (ref)

67 (52.3%)

61 (47.7%)

 Mixed

4 (57.1%)

3 (42.9%)

0.738

1.37 (0.22–8.59)

 Spongiform

3 (60%)

2 (40%)

0.921

1.13 (0.11–11.8)

 Isoechoic (ref)

10 (71.4%)

4 (28.6%)

 Hyperechoic

28 (65.1%)

15 (34.9%)

0,664

1.34 (0.35–5.06)

 Hypoechoic

25 (53.2%)

22 (46.8%)

0,232

2.20 (0.60–8.12)

 Markedly hypoechoic

11 (30.6%)

25 (69.4%)

0,012

5.68 (1.44–22.4)

 Wider-than-tall (ref)

72 (60.0%)

48 (40.0%)

 Taller-than-wide

2 (10.0%)

18 (90.0%)

0.001

13.5 (2.94–61.9)

 Regular

66 (69.5%)

29 (30.5%)

 Lob/irregular

8 (17.8%)

37 (82.2%)

< 0.001

10.5 (4.32–25.6)

 Absent

70 (60.9%)

45 (39.1%)

-

 Macrocalcifications

0 (0%)

3 (100%)

 Peripheral calcification

1 (50%)

1 (50%)

 Microcalcifications

3 (15%)

17 (85%)

–

 Yes

4 (16.0%)

21 (84.0%)

 No

70 (60.9%)

45 (39.1%)

< 0.001

8.17 (2.60–25.7)